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    Home > Active Ingredient News > Study of Nervous System > For the first time, Bi Yan's team at Nanjing University found that exosomes mediate fat-brain-to-brain communication and promote the occurrence of diabetic cognitive dysfunction

    For the first time, Bi Yan's team at Nanjing University found that exosomes mediate fat-brain-to-brain communication and promote the occurrence of diabetic cognitive dysfunction

    • Last Update: 2022-09-14
    • Source: Internet
    • Author: User
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    Diabetes significantly increases the risk of cognitive impairment (including mild cognitive impairment and dementia), seriously threatening healthy survival in



    Abnormal adipose tissue function plays an important role



    In addition to soluble adipokines, recent studies have found that adipose tissue can also secrete extracellular vesicles (EVs) as novel aliphatic factors that play an important role in inter-organ communication, such as liver and skeletal muscle, and are involved in the development of



    On September 6, 2022, the team of Professor Bi Yan of the Department of Endocrinology of Gulou Hospital Affiliated to Nanjing University School of Medicine, together with Professor Zhang Chenyu and Associate Professor Li Liang of the School of Life Sciences of Nanjing University, published a paper entitled :Extracellular vesicles mediate the communication of adipose tissue with brain and promote The research paper on cognitive impairment associated with insulin resistance has found for the first time that exosomes mediate fat-brain-to-brain communication and promote the occurrence




    The research team first used fat grafting to study the role of



    In order to further investigate whether adipose tissue-derived EVs are directly involved in the occurrence of diabetic cognitive dysfunction, the researchers treated normal mice with high-fat mice and adipose-derived EVs from diabetic patients by tail vein injection and hippocampal stereotactic injection, respectively, and found that normal mice had significant synaptic loss and cognitive function impairment



    Previous studies have shown that miRNAs are key molecules



    Finally, they studied the relationship


    In summary, the innovation of the study is reflected in: 1) the discovery of a new fat-brain information exchange pathway: adipose tissue EVs; 2) Discover a new mechanism for the occurrence of diabetic cognitive dysfunction: diabetic adipose tissue EVs can cause synaptic loss and cognitive impairment; 3) Discover adipose tissue EVs and miRNAs within them as new targets for the treatment of diabetic cognitive dysfunction
    .
    Dr.
    Wang Jin, a member of Bi Yan's research group, and Associate Professor Li Liang of the School of Life Sciences of Nanjing University are the co-first authors of the paper, Dr.
    Zhang Zhou, Dr.
    Zhu Ye, Master Zhang Xuhong, and Professor Zhang Chenyu of the School of Life Sciences of Nanjing University are the co-authors, and Professor Bi Yan is the corresponding author
    of the paper.
    Thesis link: https://doi.
    org/10.
    1016/j.
    cmet.
    2022.
    08.
    004
    open reprint welcome to forward to the circle of friends and WeChat group

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