For the first time, Chinese scientists have discovered that microsporidium poles infest related recepposor proteins.

Recently, Chinese scientists in the field of microsporidium research made a new breakthrough, the first discovery of microsporidium polar tube infestation host process recepposed protein, and proposed the microsporidium polar tube infection mechanism.
this is of great significance for the prevention and treatment of future microsporidium diseases such as silkworms, fish and humans, and the relevant research results have been published online in the international journal Pathogens.
Microsporidium is an important insect pathogen microorganism, which can cause economic losses to silkworm farming and aqua-industry by infecting silkworms and fish, and poses a serious threat to human health, especially the health of people with immune system defects such as AIDS patients and organ transplanters.
since the discovery of the first case of microsporidium in 1857, the study of receptors of microsporidium polar protein has been a blank in the field of microsporidium research.
The paper studies the interaction between microsporidium polar protein 4 (PTP4) and the host surface receptacle protein- transhelin receptacle 1 (TfR-1), and proposes the molecular mechanism of microsporidium's polar tubes to infect host cells with the help of host TfR-1 receptacle-mediated endocrine.
"The microsporidium's poles are like 'infusion tubes' during the invasion of the host, while the polar protein 4 is equivalent to the 'infusion tube' at the front end of the infusion tube," explains Professor Zhou Zeyang, author of the paper's communication and national key laboratory for silkworm genomic biology at Southwest University. Needles', microsporidium will transport its genetic material (protositor) through the 'infusion tube' to the surface of the host cell, 'needles' and the host's surface receptacle proteins interoperability, invasion into the host cells.
" was carried out by Zhou Zeyan's research team in collaboration with Professor Louis Weiss of the Albert Einstein College of Medicine in the United States.
Zhou Zeyang, the study provides a new target for the future full analysis of microsporidium infection mechanism, for silkworms, fish and human-related microsporidium disease prevention and control is of great significance.
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