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    Home > Food News > Food Articles > For the first time, Chinese scientists have realized the lone male reproduction of mammals

    For the first time, Chinese scientists have realized the lone male reproduction of mammals

    • Last Update: 2021-03-14
    • Source: Internet
    • Author: User
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    male reproductive mice came to life for the first time. Wang Leyun
    month from the next Singles' Day, two male mice were happy to crystallize the news in a circle of friends fried pot.
    Li Wei, Zhou Qi and Hu Baoyang of the Institute of Zoology of the Chinese Academy of Sciences jointly published a paper on
    announcing the first realization of mammalian lone male reproduction. Offspring of two male mice genetically combined had the first chance to breathe the world's air - albeit in just two days.
    study proves that the main barrier to male reproduction in mammals is the imprinted gene, and is the first to confirm that we can overcome these barriers. Yang Yungui, a researcher at the Beijing Genomics Institute of the Chinese Academy of Sciences who was not involved in the study, said, "This is important for us to understand the evolution and function of imprint genes and their role in development and disease."
    Yang Yungui said that the "stamp gene" is how to block the lone male reproduction, Chinese scientists have lifted what can not seal, you want to understand?in the world of fish, amphibians, reptiles and even birds, babies are sometimes born with just one supermoon mother - a phenomenon known as "lone female reproduction." But in the mammalian world, "yin and yang" has always been the same way to have children.
    have long found that the imprint gene, which is common in mammals, is a powerful seal for heterosexuals. The presence of these genes makes it possible for embryos produced by lone males and females to survive the due date.
    also like "climbing branches", mainly in mammals and higher plants. Even in mammals, it is mainly concentrated in higher real animal sub-gangs (mammals with placentals). In the more primitive, no placental platypus, kangaroos and other animals, the imprint gene is either very small or not found. Why is that?
    Li Wei told China Science Daily that the academic community has not yet decided on this phenomenon. However, some scholars speculate that compared with egg-laying fish, reptiles and other animals, placental mammals have a long period of pregnancy, the number of children is small, the mother will also face difficult to give birth to death and other huge risks. Eugenics and eugenics are therefore essential to them.
    over-reliance on same-sex reproduction can lead to the loss of genetic diversity in populations, leading to species degradation and even extinction. Mammals have evolved heterosexual die-die powder, the imprint gene, perhaps precisely to avoid competition for sexual reproduction by same-sex reproduction.more than a decade ago, a team at Tokyo Agricultural University in Japan obtained the first surviving lone female reproductive mouse, Hui Nightingi, by removing the imprint area. This proves that scientists may be able to remove the "curse seal" of the imprint gene on same-sex reproduction. But it soon became apparent that Hui was a slow-growing, nervous woman, and it was clear that scientists could not be satisfied.
    technique used by Ms. Huang involves using immature egg cells to carry knock-out genes. This method is subject to genetic laws.
    this time, Chinese researchers decided to take a different approach, using hematopoietic stem cell technology to "clean" the imprint. Stem cell technology has proven to improve not only the reproduction of lone females, but also the possibility of previously unimaginable lone male reproduction.
    "We're lucky. "The genomic imprint is a methylation modification on DNA, " Li Zhixuan, the paper's first author and a postdoctoral student at the Institute of Animals, told China Science Daily. Usually this methylation is very stable and very difficult to remove. After a series of complex operations and analyses,
    were pleasantly surprised to find that the monolithic stem cells showed a more complete "imprinted state" similar to the original reproductive cells than immature eggs, which was the basis for the experiment's ultimate success.to remove more than 20 imprinted genes from mice's genomes? "At the beginning of the experiment, it was completely unknown." Li Wei said.
    researchers first tried to improve the reproduction of lone females. In addition to the two imprint genes removed by Japanese scientists, they screened the third site to be removed and obtained almost the same solitary female reproductive mice as normal mice.
    as for the lone male reproductive mice, it's all about groping. "Our idea was simple at first, to pick the genes that are most often mentioned in the literature and are most closely related to disease." Li said.
    's lucky to be there again. After removing the 7th imprint gene, some embryos were successfully born from the surrogate mother's womb after 19 days of conception.Many of the imprint genes found are associated with serious human diseases, including mental disorders (certain autism), metabolic diseases (BWS syndrome, etc.), growth and developmental abnormalities (little fat Willie syndrome, etc.), which are collectively referred to as "single-parent twice-factor diseases." Due to the large number of imprinted genes, there are many patients with single-parent double disease.
    ", which repairs these abnormal imprint segments in the patient's body, may have therapeutic effects. "In theory, lone females and lone male mice have concentrated on a variety of possible single-parent double abnormalities, and our knock-out operation can be considered a 'fix'. We hope this study will provide an operational platform to screen out the initial ways to repair more imprint segments. We30 countries around the world have legalized same-sex marriage. Same-sex couples will inevitably look forward to more happiness when they get their marriage licenses: can we have our own children as science and technology advance?
    is similar to IVF, which also fuses reproductive cells from two individuals in-body and then transfers the resulting early embryos into the female's womb. However, scientists have made bold explorations to allow the traditional sexual reproduction of fine eggs, can be "egg binding" or even "fine binding" can be replaced. This seems to mean that two people of the same sex may also have offspring that carry both genes.
    theory, but at the moment it seems too risky. "From the current mouse experimental data, the success rate of lone female reproduction is 10% to 20%, only 2% of lone male reproduction. This success rate is not clinically acceptable. He
    he further pointed out that mice that reproduced alone could only survive for a short period of time. Even if the mice reproduced by lone females look normal under laboratory conditions, there is no guarantee that they will break into the world like normal mice. (Source: Li Chenyang, China Science Journal)
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