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The research team from the Institute of Zoology, The Institute of Biophysics, the Institute of Stem Cells and Regenerative Medicine Innovation of the Chinese Academy of Sciences, after three years of efforts, realized for the first time SIRT6 in non-human primates in the whole body knockout, obtained the world's first specific longevity gene knockout crab monkey model.
significantly different from the accelerated aging phenotype in the SIRT6 knockout mice, the crab-eating monkeys that sirT6 knocked out died within hours of birth.
multiple analyses showed that the crab-eating monkeys that SIRT6 knocked out did not show accelerated aging phenotypes, but showed severe systemic developmental delays.
newborn SIRT6 knockout monkey's brain, muscles and a variety of other organ tissues showed significant embryonic immature cell and molecular characteristics.
, studies using human stem cell models have shown that the lack of SIRT6 can also block the differentiation of human neural stem cells into neurons. further molecular mechanism studies
found that SIRT6 can reverse inhibit the expression of H19 by mediatating the formofprotein deacetylization of the mediated region of the long chain non-coding ribonucleic acid H19 imprinting region, while the lack of SIRT6 would cause abnormal increases in H19 expression in primate neuroprecursor cells, which in turn lead to brain developmental delay.
published the results online August 22 in the international academic journal Nature.
the first combination of non-human primate models, human stem cell models and gene editing techniques revealkey molecular switches that regulate pre-birth development procedures in primates, providing an important model for the study of pre-birth developmental retardation syndrome.
in addition, the study reveals for the first time the huge differences between primates and rodents in the pathways of aging regulation, providing an important basis for research into the mechanisms of human development and aging, as well as for the intervention of related diseases.
the research was carried out in collaboration with the Institute of Zoology of the Chinese Academy of Sciences, the Institute of Biophysics, the Institute of Stem Cell and Regenerative Medicine Innovation, the Xuanwu Hospital of Capital Medical University, the First Hospital affiliated with Peking University and Zhongshan University. Hu Baoyang, Li Wei and Liu Guanghui, researchers at the Institute of
Animals, are co-authors of the paper. Zhang Weiwei, a researcher at the Institute of Biophysics of
, Wan Haifeng, an assistant researcher at the Institute of Animals, Feng Guihai, an associate researcher, and Qu Jing, a researcher, are co-authors. Zhou Qi, a member of the Chinese Academy of Sciences in
, has given important support and guidance to the development of the work.
the research was supported by the Chinese Academy of Sciences " organ reconstruction and manufacturing" strategic science and technology pilot special and the Ministry of Science and Technology, the Fund Committee and so on.
.