For the first time in the world, Chinese scientists have interpreted the complete dynamic process of homesuating hematopoietic stem cells in the world.

On November 19th Nature, a leading international journal, published a major breakthrough for Chinese scientists.
the Chinese Academy of Sciences Shanghai Institute of Nutrition and Health Institute Pan Weijun researcher team, lasted 6 years, the world's first high-definition analysis of the body hematopoietic stem cell homecoming complete dynamic process, opened up a new era of hematopoietic stem cell long-term in-body research.
. Hematopoietic stem cells contain red blood cells, white blood cells, platelets and other types of cells in the blood.
they come in different shapes and functions, but they share a common source, hematopoietic stem cells.
as the ancestral cells in the human blood system, hematopoietic stem cells have the ability to renew themselves, and can produce all blood cell types by proliferation and differentiation to maintain life.
hematopoietic stem cells in the circulatory system to find their most suitable microenvironment process is called "home", only to find their own "home", hematopoietic stem cells can effectively play their function.
in a healthy physiological state, hematopoietic stem cells seem to carry a GPS, always find its best location.
, how did these hematopoietic stem cells find their right place? This is a problem that many teams of scientists are trying to figure out.
. However, due to the "hematopoietic stem cell home" this life process of the time-space span is very large, its specific mechanism of occurrence has been unknown.
to overcome this scientific problem, the Chinese Academy of Sciences Shanghai Institute of Nutrition and Health Researcher Pan Weijun led his research team, lasted 6 years, integrated genetic regulation, immunofluoriating markers and live imaging and other technologies, formed a new research system.
the system can directly observe the complete process of returning new hematopoietic stem cells to nest in the body.
through a large number of statistical analysis and experimental verification, the research team for the first time to clarify the hematopoietic stem cells home to the temporal law, found the hematopoietic stem cells in the hematopoietic tissue to stay in the nest of the "hot spot area" and the special venous microvascular structure.
In addition, they have discovered a new subgroup of macrophages that can identify and guide stem cells to their nests in the "hot spots" where they remain in the nest, and name them "pilot cells."
. For the first time, the study visually records the interaction mechanism between cells and the microenvironment at various stages of the nest through live imaging, and illustrates the dynamic collaboration process between cells of different tissues in the course of life.
these findings greatly enrich the existing scientific understanding of the mechanism of hematopoietic stem cell nesting.
this achievement is an original and important scientific discovery independently completed by Chinese scientists, which marks the beginning of a new era of long-range, high-resolution and physical research in the field of international hematopoietic stem cells. Professor Chen Wei, director of the hematology department at Huashan Hospital affiliated with Fudan University,
, said the discovery bodes well for the return of targeted, targeted induced hematopoietic stem cells in clinical stem cell transplantation, thus greatly increasing the success rate of future hematopoietic stem cell transplantation.
Source: Biological Exploration.