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    Home > Active Ingredient News > Antitumor Therapy > For this part of early breast cancer patients, adjuvant chemotherapy is useless!

    For this part of early breast cancer patients, adjuvant chemotherapy is useless!

    • Last Update: 2022-08-19
    • Source: Internet
    • Author: User
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    Breast cancer (BC) is the most common malignancy in women and the leading cause of cancer-related death in women worldwid.


    BC is a heterogeneous disease that responds markedly to treatment and consists of 4 distinct molecular subtype.


    75,000 patients diagnosed with T1N0M0 BC were selected from the Surveillance, Epidemiology and End Results (SEER) databas.


    With a median follow-up of 51 months, a total of 75139 patients with T1N0M0 BC were divided into three groups: T1a (n = 10073); T1b (n = 24951); and T1c (n = 40115.


    In T1b BC, adjuvant chemotherapy was found to have significant effects on grade III and hormone receptor+ (HR+)/human epidermal growth factor receptor 2+ (HER2+), HR-/HER2+ and HR-/HER2- molecular subtypes, respectively influenc.


    Adjuvant chemotherapy is beneficial for OS in grades II/III and T1c B.


    We also obtained similar results in the external validation cohort, except that adjuvant chemotherapy produced differences in grade II and T1b BC in the external validation datase.


    The study found that adjuvant chemotherapy is not beneficial and may even be harmful for patients with T1aN0M0 B.


    Original source:

    Shen K, Yao L, Zhu J, Gu X, Wang J, Qian W, Zheng Z, Fu D, Wu .


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