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Recently, the Peking University-Tsinghua Life Sciences Joint Center and the Peking University School of Chemistry and Molecular Engineering Department of Applied Chemistry Liu Zhibo's group published a research paper in "Angewandte Chemie International Edition", which is different from the classic biological chemistry control strategy.
Liu Zhibo's project Through the introduction of cationic micelles as the "living catalyst", the group selectively increased the rate constant of the desiliconization reaction in the tumor, and regulated the living shear chemistry from a brand new perspective
.
Figure 1.
Cationic micelles catalyze the chemistry of boronic acid-mediated desiliconization and shearing
Many important biological chemistry are second-order reactions, the reaction rate of which depends on the rate constant and the concentration of the two reactants
.
Therefore, the use of the targeting of reactants to achieve their enrichment in specific tissues, and to increase their local concentration, is an important means to regulate in vivo chemistry and achieve controllable release
Inspired by the adsorption mechanism of radioactive ions and related materials in the field of radiochemistry, Liu Zhibo’s team discovered that cationic micelles commonly used in mRNA drugs can act as catalysts to accelerate their recent development of in vivo desiliconization reactions (Nature, 2020, 579, 421-426) ; J.
Am.
Chem.
Soc.
, 2021, 143, 2250-2255)
.
The micellar catalysis can increase the desiliconization rate constant by more than 1,400 times, and can be performed efficiently in test tubes, live cells, and animal models, thereby achieving controlled release of drugs in tumors
Figure 2.
New micelles (PC7BA) responding to the slightly acid system are used for tumors to selectively accelerate the in vivo desiliconization reaction
Taking into account that cationic micelles will be quickly cleared in the body's circulation, traditional cationic micelles cannot achieve tail vein administration
.
Therefore, the author constructed a new type of micellar system that responds to slightly acidic environments
Wang Chunhong, a doctoral student in the School of Chemistry and Molecular Engineering of Peking University, is the first author of the article, and researcher Liu Zhibo is the corresponding author
.
Professor Li Zichen from the School of Chemistry and Molecular Engineering of Peking University also made important contributions to this work