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    Home > Food News > Food Articles > From the synthesis of a protein to the synthesis of life, Shanghai leads the life sciences

    From the synthesis of a protein to the synthesis of life, Shanghai leads the life sciences

    • Last Update: 2021-02-28
    • Source: Internet
    • Author: User
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    Shanghai accelerates its march into the center of scientific and technological innovation with global influence, and the physical model of "the first international artificial creation of a single chromosome of the nucleocytes" is on display at the Science and Technology Innovation Exhibition.recently, the
    Shanghai Pharmaceutical Research Institute geng Meiyu team and the Shanghai Green Valley Pharmaceutical Research Institute joint research team jointly revealed the new pathogenesis of Alzheimer's disease. Meanwhile, their anti-Alzheimer's sugar drug GV-971 is being approved for new drugs that, once on the market, will break the silence of the world's 16-year-old drug market.
    just last year, two life sciences achievements from Shanghai, the world's first sophyte cloned monkeys and the first international artificial creation of a single chromosome total nucleus, topped China's top 10 scientific and technological advances in 2018. At the same time, the human esophageal group plan, protein labeling program and other life science field of the international large-scale scientific program, is being bred in Shanghai, the future China is expected to dominate the development direction of these areas in the future, "leading" international related life science research.
    looking back on the 70-year struggle history of New China, Shanghai, as a major city of life science research in China, has always responded positively to the country's major needs, stood at the forefront of the world, and made a Chinese voice. From the early liberation of scientific research "zero starting point", to the mid-1960s "synthetic protein", to now "synthetic life", this bold, courage to climb the peak of the pioneering spirit, has been in Shanghai on this side of innovation hot soil surge, flow.the process of synthetic fully synthesized crystalline bovine insulin, Zhai Yueting (left) and Jiang Rongqing (right) of the Shanghai Institute of Biochemistry of the Chinese Academy of Sciences observed the recombination results of synthetic B-chain and natural A-chain.The synthetic bovine insulin is one of the few Nobel Prize-level achievements in the 70-year history of science and technology development in New China. In the 1960s, it was born like "two bombs and one star" in national defense science and technology, for the new China's basic scientific research to win the world's attention and respect.
    1958, researchers at
    Institute of Biochemistry in Shanghai, China, proposed to "synthesize a protein". And just three years ago, in 1955, the British journal Nature predicted: "Synthetic insulin will be a distant thing." "
    is it to synthesize a "live" protein? In the 1950s, the only simple amino acid synthesized in China was sodium glutamate, or MSG. Synthesis of a protein requires the accurate synthesis and successful crystallization of tens of thousands of amino acids through more than 200 chemical reactions, ultimately ensuring its biological activity. It has been estimated that a chemical solvent used in synthesis alone would be sufficient to fill a standard swimming pool.
    through the scientific researchers to work together, and strive to synthesize insulin work "step by step" forward. In the early morning of September 17, 1965, scientists finally saw a crystalline flash in the test tube!
    Following the synthetic bovine insulin, Shanghai scientists joined forces with their national scientific counterparts for many years to create the first synthetic chemical structure and natural molecules in 1981, biologically active nucleic acid large molecules - composed of 76 nucleotides of the whole molecule yeast alanine transfer ICS, marking China's entry into the world's advanced ranks in this field.
    new century, scientists have goes from "synthetic life molecules" to "synthetic life". Last year, Shanghai scientists "synthetic monochromosome yeast" related papers published in the British journal Nature, once again made a major breakthrough in the field of artificial life synthesis.the founding of New China, a hundred waste to be happy, everywhere need science and technology to solve the emergency. In that epidemic epidemic, lack of medical treatment and medicine, the use of their research base in the field of life sciences for the country to solve problems, has become the Shanghai scientists' greatest hope.
    1953, the Shanghai Antibiotic Research Conference, composed of natural organic chemists, drugologists and microbiologists
    , was established. Shanghai scientists rushed ahead, at that time in the production of "blank" penicillin, streptomycin, kimmycin and other antibiotics, will work with the industrial sector, from the species screening, fermentation process, chemical extraction and other aspects of cooperation. Soon, these antibiotics were put into production, which made great contribution to the establishment of our country's antibiotic industry.
    the founding of New China, life expectancy in China was only 35 years, rising to 57 years in 1957, and the rapid establishment of the antibiotic industry undoubtedly played an important role in it.
    around the country's major population health needs, Shanghai in the research and development of new drugs continue to innovate, to "do people can afford to eat good medicine" as its own responsibility. In 1987, the antimalarial drug artemisinin ether, developed by Shanghai researchers, became the first independent research and development drug in China to receive international recognition. Until now, the "baton" of artemisinin research has been passed on.
    Shanghai Drug Institute is moving artemisinin from cultivation to drug production to Africa to bring antimalarial drugs closer to those who need them.
    From the early days of the founding of New China mainly imitation drugs, to the subsequent stage of imitation innovation, into the new century, Shanghai new drug research and development is gradually moving towards the real original innovation - the discovery of disease development mechanism, open up new drug research and development areas and research and development models. About 20 years ago, the
    Shanghai Drug Institute Geng Meiyu team began the research and development process of anti-Alzheimer's drug GV-971, and now, this is about to end the Shanghai original innovative drug is not only expected to rewrite the status quo of Alzheimer's patients without drugs, but also foreshadow china's sugar drug research and development in the key technology system and research and development model to the forefront of the world, is expected to walk out of a new Chinese drug creation of the "sugar road."
    , located in Zhangjiang Pharmaceutical Valley, Pudong, after more than 20 years of development, has developed a new drug research and development platform that can cover all aspects of new drug research and development. As one of the key areas of Shanghai's strategic emerging industries, the biopharmaceutical industry achieved a total economic output of 343.388 billion yuan last year, an increase of 4.49%, of which the manufacturing industry grew by 9.8%.research often requires the accumulation of several generations, it is the backing of technological innovation, but also the cornerstone of industrial development.
    Looking back 70 years of unremitting struggle, from the world's first "grandfatherless
    ", to the birth of the world's first solithocyte cloned monkeys, from macaque learning memory research, to the development of brain and brain intelligence, from participation in the International Human Genome Project, to the launch of the International Great Science Program of the Human Estrom group, Shanghai scientists for the "world's first" pursuit, gradually breakthrough from the point to establish a unique systematic research.
    the beginning of 2018, the world's first sombo cell clone monkey "China" was born. In just one year, a model monkey with circadian rhythm disorder, developed using sophyte cell cloning technology, has been developed. At the same time, located in Songjiang District, G60 brain science and intelligence base has also started construction, the future will form a set of non-human primate model animal breeding, brain science and brain disease research, brain intelligence research and other world-class research center, become the global biomedicine "primate era" benchmark.
    original! Original! It's still original! In the Shanghai Science and Technology Awards, almost every year you can see the "ten years grinding a sword" or even "twenty years grinding a sword" project, in Shanghai's universities and research institutes, more and more mentors encourage young students to put aside their concerns about the future, challenge world-class problems, in the original innovation. At the same time, science and technology policy is also to give original scientific research long-term stable support in the direction of efforts.
    looking to the future, we have reason to believe that Shanghai Life Sciences will contribute more original impetus to enhancing Shanghai's innovation capabilities on its new journey towards a globally influential science and technology innovation center.
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