From treating AIDS drugs to increasing the treatment of COVID-19 indications, how does Chang Junbiao do it?

"One minute on stage, ten years offstage

"One minute on stage, ten years offstage

With the approval of China's first new crown special drug, Azifding has become the focus

With the approval of China's first new crown special drug, Azifding has become the focus

But what is not known is that it was his 18 years of obscure persistence that could win a heavy new class of drugs

But what is not known is that it was his 18 years of obscure persistence that could win a heavy new class of drugs

He is Professor

He is Professor

From treating AIDS drugs to increasing the treatment of COVID-19 indications, how does Chang Junbiao do it?

From treating AIDS drugs to increasing the treatment of COVID-19 indications, how does Chang Junbiao do it?

New anti-AIDS drugs

Anti-AIDS New Drugs Anti-AIDS New Drugs Anti-AIDS New Drugs

Azfedine

Azfding Azfudine Azfding

"Research and development of Azfedine began in 2004 and has been around for

"Research and development of Azfedine began in 2004 and has been around for

At that time, the number of AIDS patients in China increased rapidly, and the rate of transmission accelerated, but at that time, it could only rely on expensive foreign imported drugs for treatment

At that time, the number of AIDS patients in China increased rapidly, and the rate of transmission accelerated, but at that time, it could only rely on expensive foreign imported drugs for treatment

Chang Junbiao keenly saw this clinical need and decided to start experimenting

Chang Junbiao keenly saw this clinical need and decided to start experimenting

"10 years, 1 billion US dollars" is used to describe the difficulty of innovative drug research and development, and Chang Junbiao is no exception
.

"10 years, 1 billion US dollars" is used to describe the difficulty of innovative drug research and development, and Chang Junbiao is no exception
.
"10 years, 1 billion US dollars" is used to describe the difficulty of innovative drug research and development, and Chang Junbiao is no exception
.
"10 years, 1 billion US dollars" is used to describe the difficulty of innovative drug research and development, and Chang Junbiao is no exception
.

He led the team into the lab, and the first problem they faced was how to design new nucleoside antiviral drugs
.

He led the team into the lab, and the first problem they faced was how to design new nucleoside antiviral drugs
.

Because the screening of HIV in vitro activity needs to be carried out in the P3 laboratory, there are too few relevant laboratories in China, which often makes the research and development progress stagnate
.

Because the screening of HIV in vitro activity needs to be carried out in the P3 laboratory, there are too few relevant laboratories in China, which often makes the research and development progress stagnate
.

Chang Junbiao often looks for corporate investment while leading the team in research and development
.

Chang Junbiao often looks for corporate investment while leading the team in research and development
.

Finally, in 2013, the HIV reverse transcriptase (RT) inhibitor Azifdine was licensed by the State Food and Drug Administration to enter the clinic
.

Finally, in 2013, the HIV reverse transcriptase (RT) inhibitor Azifdine was licensed by the State Food and Drug Administration to enter the clinic
.

Everything is difficult at the beginning, but entering the first phase of clinical practice does not mean that everything is lucky
.

Everything is difficult at the beginning, but entering the first phase of clinical practice does not mean that everything is lucky
.
Everything is difficult at the beginning, but entering the first phase of clinical practice does not mean that everything is lucky
.
Everything is difficult at the beginning, but entering the first phase of clinical practice does not mean that everything is lucky
.

Drug design, synthesis, pharmacodynamic testing, safety testing.
.
.
In the process of research and development, Chang Junbiao and the team have made extraordinary hard efforts
.

Drug design, synthesis, pharmacodynamic testing, safety testing.
.
.
In the process of research and development, Chang Junbiao and the team have made extraordinary hard efforts
.

One year Chinese New Year's Eve, Chang Junbiao's family wrapped dumplings at home, and they could not see him go home to eat, so they had to go to the laboratory to celebrate the New Year with Chang Junbiao, which belonged to the special new year of
scientific researchers.

One year Chinese New Year's Eve, Chang Junbiao's family wrapped dumplings at home, and they could not see him go home to eat, so they had to go to the laboratory to celebrate the New Year with Chang Junbiao, which belonged to the special new year of
scientific researchers.

Chang Junbiao's efforts were not in vain
.

Chang Junbiao's efforts were not in vain
.
Chang Junbiao's efforts were not in vain
.
Chang Junbiao's efforts were not in vain
.

Two years later, in 2015, Azfedine received Phase II.
/III.
clinical approval
.

Two years later, in 2015, Azfedine received Phase II.
/III.
clinical approval
.

Until 2021, Azvedine was approved for marketing as an anti-HIV drug, becoming the world's first dual-target anti-AIDS innovative drug
.

Until 2021, Azvedine was approved for marketing as an anti-HIV drug, becoming the world's first dual-target anti-AIDS innovative drug
.

One product

One product, one product, one product

Two missions

Two missions Two missions Two missions

At the beginning of 2020, the new crown epidemic broke out in China, and the research on special drugs could not be delayed
.

At the beginning of 2020, the new crown epidemic broke out in China, and the research on special drugs could not be delayed
.

Chang Junbiao's team, who has many years of experience in antiviral drug research, took the initiative to undertake the henan province novel coronavirus prevention and control emergency scientific research project "anti-novel coronavirus drug screening"
.

Chang Junbiao's team, who has many years of experience in antiviral drug research, took the initiative to undertake the henan province novel coronavirus prevention and control emergency scientific research project "anti-novel coronavirus drug screening"
.

Because azvedine has a broad-spectrum antiviral and anti-cancer effect, Chang Junbiao conducted a new indication study
on azfribatine against the new crown.

Because azvedine has a broad-spectrum antiviral and anti-cancer effect, Chang Junbiao conducted a new indication study
on azfribatine against the new crown.
Because azvedine has a broad-spectrum antiviral and anti-cancer effect, Chang Junbiao conducted a new indication study
on azfribatine against the new crown.
Because azvedine has a broad-spectrum antiviral and anti-cancer effect, Chang Junbiao conducted a new indication study
on azfribatine against the new crown.

After entering the second phase of clinical trials, Chang Junbiao found that the relationship between the dose and effect of the drug was not obvious, and it was necessary to further study the mechanism of action to observe the actual distribution of the drug in the human body, and it was urgent to recruit volunteers
.

After entering the second phase of clinical trials, Chang Junbiao found that the relationship between the dose and effect of the drug was not obvious, and it was necessary to further study the mechanism of action to observe the actual distribution of the drug in the human body, and it was urgent to recruit volunteers
.

Chang Junbiao was the first to sign
up.

Chang Junbiao was the first to sign
up.

Under his leadership, Chang Junbiao's students, laboratory colleagues, and relatives all signed up one by
one.

Under his leadership, Chang Junbiao's students, laboratory colleagues, and relatives all signed up one by
one.

Through the comparison of the results of the drug concentration analysis in the blood of more than a dozen subjects, it was proved that Azfu was able to target the distribution of human peripheral blood mononuclear cells, and the active metabolites were effectively maintained for 4-5 days after a single dose; The single nuclear cell targeting coefficient is more than 140 times
that of another commonly used drug.

Through the comparison of the results of the drug concentration analysis in the blood of more than a dozen subjects, it was proved that Azfu was able to target the distribution of human peripheral blood mononuclear cells, and the active metabolites were effectively maintained for 4-5 days after a single dose; The single nuclear cell targeting coefficient is more than 140 times
that of another commonly used drug.

This conclusion provides a reliable basis for azistine as a long-acting oral antiviral drug, and also gives a reasonable explanation for the results of clinical trials
.

This conclusion provides a reliable basis for azistine as a long-acting oral antiviral drug, and also gives a reasonable explanation for the results of clinical trials
.
This conclusion provides a reliable basis for azistine as a long-acting oral antiviral drug, and also gives a reasonable explanation for the results of clinical trials
.
This conclusion provides a reliable basis for azistine as a long-acting oral antiviral drug, and also gives a reasonable explanation for the results of clinical trials
.

In July this year, Professor Chang Junbiao and Real Bio announced the results of a key phase III clinical trial of a multicenter, randomized, double-blind, and placebo-controlled Azfriculture:

In July this year, Professor Chang Junbiao and Real Bio announced the results of a key phase III clinical trial of a multicenter, randomized, double-blind, and placebo-controlled Azfriculture:

Azvodine has been shown to significantly improve clinical symptoms, inhibit THE activity of the new crown virus, and overall well
tolerated.

Azvodine has been shown to significantly improve clinical symptoms, inhibit THE activity of the new crown virus, and overall well
tolerated.

On July 25, Azfding was approved for listing, becoming the first new crown special drug in China, and Chang Junbiao was extremely
pleased.

On July 25, Azfding was approved for listing, becoming the first new crown special drug in China, and Chang Junbiao was extremely
pleased.

Virus Fighter

Virus Fighter Virus Fighter Virus Fighter

The heart is like a mirror

The heart is like a mirror, the heart is like a mirror

When Chang Junbiao was studying for a doctorate, he studied under Xie Jingxi, a famous medicinal chemist in China, and invented 5 new Class 1 drugs
.

When Chang Junbiao was studying for a doctorate, he studied under Xie Jingxi, a famous medicinal chemist in China, and invented 5 new Class 1 drugs
.

Although he is nearly 100 years old, Mr.
Lao is still in good spirits, always paying attention to the drug research and development progress of student Chang Junbiao, and often goes to Henan to discuss academic issues
with him.

Although he is nearly 100 years old, Mr.
Lao is still in good spirits, always paying attention to the drug research and development progress of student Chang Junbiao, and often goes to Henan to discuss academic issues
with him.

"I hope that in my lifetime, I will see you develop more new drugs
.
"

"I hope that in my lifetime, I will see you develop more new drugs
.
" "I hope that in my lifetime, I will see you develop more new drugs
.
" "I hope that in my lifetime, I will see you develop more new drugs
.
"

Chang Junbiao always remembers this entrustment
.

Chang Junbiao always remembers this entrustment
.

With the increase of applications for the registration of new crown indications for the treatment of Azfding, Chang Junbiao is still not arrogant and impatient, playing the role
of "virus fighter" in the front line of scientific research.

With the increase of applications for the registration of new crown indications for the treatment of Azfding, Chang Junbiao is still not arrogant and impatient, playing the role
of "virus fighter" in the front line of scientific research.

But in life, Chang Junbiao pursues minimalism, as clean and flawless
as a mirror.

But in life, Chang Junbiao pursues minimalism, as clean and flawless
as a mirror.

Traveling, just discussing topics in another place; The cuffs of the clothes are torn, and there is no time to buy them; The most commonly eaten fast food is the corn paste and dumplings
made in the hometown.

Traveling, just discussing topics in another place; The cuffs of the clothes are torn, and there is no time to buy them; The most commonly eaten fast food is the corn paste and dumplings
made in the hometown.
Traveling, just discussing topics in another place; The cuffs of the clothes are torn, and there is no time to buy them; The most commonly eaten fast food is the corn paste and dumplings
made in the hometown.
Traveling, just discussing topics in another place; The cuffs of the clothes are torn, and there is no time to buy them; The most commonly eaten fast food is the corn paste and dumplings
made in the hometown.

"Only simple and pure can we maintain that focus and enthusiasm
.
" Family commented
.

"Only simple and pure can we maintain that focus and enthusiasm
.
" Family commented
.