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Physical activity may help reduce the risk of Alzheimer's disease (AD) , although the underlying mechanisms are not fully understo.
Physical activity may help reduce the risk of Alzheimer's disease (AD) , although the underlying mechanisms are not fully understo.
Steve Pedrini Steve Pedrini et al published a research article in Fro.
The study evaluated 143 cognitively normal older adults, all of whom had brain amyloid deposits assessed using positron emission tomography and their physical activity levels measured using the International Physical Activity Questionnaire (IPAQ.
The study evaluated 143 cognitively normal older adults, all of whom had brain amyloid deposits assessed using positron emission tomography and their physical activity levels measured using the International Physical Activity Questionnaire (IPAQ.
The study found:
Comparison of plasma biomarkers between low to moderate physical activity (LMPA) and high physical activity (HPA) groups
Comparison of plasma biomarkers between low to moderate physical activity (LMPA) and high physical activity (HPA) groupsComparison of plasma biomarker ratios between low to moderate physical activity (LMPA) and high physical activity (HPA) groups
Comparison of plasma biomarker ratios between low to moderate physical activity (LMPA) and high physical activity (HPA) groupsCorrelation of brain amyloid burden with blood biomarker levels in all study participants and stratified by physical activity level
Correlation of brain amyloid burden with blood biomarker levels in all study participants and stratified by physical activity levelBrain amyloidosis was negatively correlated with plasma β- amyloid (Aβ) 1-42 , but no correlation was found between cerebral amyloidosis and plasma Aβ1-40 and amyloid precursor protein (APP) 669-71
Brain amyloidosis was negatively correlated with plasma β- amyloid (Aβ) 1-42 , but no correlation was found between cerebral amyloidosis and plasma Aβ1-40 and amyloid precursor protein (APP) 669-71
Higher levels of physical activity were associated with plasma levels of Aβ1-40 , Aβ1-42 and APP669-711 in APOE ε4 non-carrier.
The ratios of Aβ1-40/Aβ1-42 and APP669-711/Aβ1-42 associated with high cerebral amyloidosis were different between APOE ε4 carriers and non-carrie.
In conclusion, in cognitively normal older adults, there is a complex relationship between physical activity and brain amyloid deposition and potential blood biomarkers for A.
original source
The Association Between Alzheimer's Disease-Related Markers and Physical Activity in Cognitively Normal Older Adul.
The Association Between Alzheimer's Disease-Related Markers and Physical Activity in Cognitively Normal Older Adul.
Fro.
Aging Neuros.
, 28 March 2022 | https://d.
org/13389/fna.
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