Front Aging Neurosci: Fructose in the brain causes Alzheimer's disease.

September 25, 2020 /--- A new study published by the University of Colorado suggests that Alzheimer's disease may be caused by excessive fructose in the brain.
the study, published in the journal Frontiers in Aging Neuroscience, makes the hypothesis that Alzheimer's disease is largely driven by Western culture and is influenced by excessive fructose metabolism in the brain.
(Photo source: www.pixabay.com) The study was carried out by an interdisciplinary team of neuroscientists and sugar metabolism experts and provided extensive data and research evidence on Alzheimer's disease, which linked high fructose levels in the brain to the disease.
also help explain why diabetes and obesity, for example, are associated with an increased risk of Alzheimer's disease.
Dr Richard Johnson, a professor at the University of Colorado School of Medicine, said: "Essentially, we believe that Alzheimer's disease is a disease driven by a modern diet that causes the accumulation of fructose in the brain, which disrupts brain metabolism and neuron function.
" Johnson outlines data showing that brain fructose metabolism is overactive and can lead to Alzheimer's disease.
of fructose comes mainly from endo-production in the brain.
, inadequate neuron glycolysis hinders the reduction of mitochondrial energy production, leading to the gradual loss of brain energy levels required for neurons to maintain function and survive.
johnson added: "With this evidence, we hope to inspire researchers to continue to explore the relationship between fructose in the brain and Alzheimer's disease."
hope to provide a novel way to prevent and treat the disease.
."
, the authors argue that in some cases, low glucose metabolism increases oxidative stress and occurs with mitochondrial loss, which eventually leads to neuron dysfunction and death.
this case, amyloid plaques and neurogen fiber tangles are part of the inflammatory response and are involved in damage, but are not the main drivers of the disease.
theory, enzymes that inhibit fructose production or metabolism in the brain may provide new ways to prevent and treat Alzheimer's disease.
(bioon.com) Source: Fructose made in the brain can be a mechanism driving Alzheimer's disease Original source: Richard J. Johnson et al, Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer's Disease, Frontiers in Aging Neuroscience (2020). DOI: 10.3389/fnagi.2020.560865.