echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Antitumor Therapy > Front Cell Infect Microbiol: Still not brushing your teeth well?

    Front Cell Infect Microbiol: Still not brushing your teeth well?

    • Last Update: 2021-06-10
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    The relationship between bacteria and cancer has always been very delicate.


    As a physiological island, the human body hosts trillions of bacteria and other microorganisms.


    Scientists have discovered that with the improvement of people's living standards, all kinds of food are corroding our teeth, so it is inevitable that we have to put on dentures.


    Not only that, these bacteria in the oral cavity will be silent.


    Proto-Oncogenes and Cell Cycle Gene Expression in Normal and Neoplastic Oral Epithelial Cells Stimulated With Soluble Factors From Single and Dual Biofilms of Candida albicans and Staphylococcus aureus

    Studies have found that fungi and bacteria in the oral cavity not only cause diseases such as periodontitis and dental caries, but also activate the expression of head and neck cancer-related genes.


    In recent years, with the in-depth understanding of some chronic and intractable diseases caused by common bacteria in the medical field, it has been discovered that biofilms are the main reason why these bacterial diseases are difficult to cure.


    Candida albicans and Staphylococcus aureus are very common in the oral cavity.


    Therefore, the researchers speculated that it might be possible to use metabolites from the bacterial biofilms of Candida albicans and Staphylococcus aureus to stimulate and attack cells in order to explore the potential connection between bacteria and cancer.


    Cell cycle distribution index

    Cell Cycle Distribution Index Cell Cycle Distribution Index

    In further experiments, the researchers also found that biofilms, as organized growth aggregates of microorganisms, secrete metabolites that can regulate the expression of proto-oncogenes and cell cycle genes related to tumor cell growth and survival, and the gene expression It mainly focuses on the signaling pathways "EGFR/RAS/RAF/MEK/ERK and EGFR/PI3K/AKT/mTOR", which play an important role in the proliferation, differentiation and survival of tumor cells.


    The expression of proto-oncogenes and cell cycle genes of soluble factors in biofilms

    Expression of proto-oncogenes and cell cycle genes of soluble factors in biofilms Expression of proto-oncogenes and cell cycle genes of soluble factors in biofilms

    All in all, this research lays the foundation for metabolomics and proteomics studies of oral biofilms.


    Currently, this research has been supported by the Sao Paulo Research Foundation (FAPESP) and the National Council for the Development of Science and Technology (CNPq).


    Original source:

    Original source:

    María Isabel Amaya Arbeláez, et al.


    Proto-Oncogenes and Cell Cycle Gene Expression in Normal and Neoplastic Oral Epithelial Cells Stimulated With Soluble Factors From Single and Dual Biofilms of Candida albicans and Staphylococcus aureus.


    Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.