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Front Immunol: A retrospective study of the replacement and immunomodulatory activity of 20% subcutaneous immunoglobulin in patients with autoimmune myositis and CVID

 Last Update: 2022-03-04
 Source: Internet
 Author: User

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Immunoglobulin (Ig) replacement therapy is a life-saving therapy for primary antibody deficiency
.

The introduction of subcutaneous immunoglobulin (SCIg) has greatly improved the quality of life of patients compared to traditional intravenous administration

This study aimed to increase knowledge on the anti-inflammatory and immunomodulatory effects of SCIg in the treatment of myositis
.

To this end, the efficacy of 20% human SCIg therapy (20% SCIg, Hizentra®, CSL Behring) was long-term assessed in PM/DM patients cared for at our center

Results support the beneficial effect and tolerability of 20% SCIg long-term treatment in PM/DM patients, reporting creatine kinase levels, muscle strength, skin condition, dysphagia, disease activity (MITAX score), and disability (HAQ-DI score) Significant improvement
.

No systemic reactions were reported in any of the patients

This study suggests that 20% SCIg in the treatment of PM/DM is a safe and feasible treatment, an effective alternative to IVIg, and has important advantages in improving the quality of life of patients

Source: Danieli MG, Verga JU, Mezzanotte C, et al.

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