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Background: Mother-to-child transmission was previously the main route of transmission of hepatitis B virus (HBV) infection in China, accounting for approximately 40% of chronic infectio.
Background: Mother-to-child transmission was previously the main route of transmission of hepatitis B virus (HBV) infection in China, accounting for approximately 40% of chronic infectio.
Objective: To this end, to analyze the clinical characteristics of patients with or without postpartum hepatitis outbreaks, and to preliminarily explore the differences in immune functi.
METHODS: Women with CHB infection who were pregnant (below 8 weeks' gestation) and who were planning to become pregnant who were treated at Beijing You'an Hospital Affiliated to Capital Medical University from July 2017 to July 2018 were selected, and agreed to undergo NA intervention in the third trimester of pregnancy to prevent maternal Infant transmissi.
Results: A total of 15 patients with postpartum hepatitis were included in the first group, and 10 matched patients were selected as the control group in the second gro.
Figure 1 | Clinical characteristics between the two grou.
Figure 1 | Clinical characteristics between the two grou.
Figure 2 | Gating strategies for CD8+ T cell populations and other marke.
Figure 2 | Gating strategies for CD8+ T cell populations and other marke.
Figure 3 | Changes in CD38 and HLA-DR-expressing CD8+ T cells and phenotypic subse.
Figure 3 | Changes in CD38 and HLA-DR-expressing CD8+ T cells and phenotypic subse.
Figure 4 | Changes in CD107a, GranB and perforin expressing CD8+ T cel.
Figure 4 | Changes in CD107a, GranB and perforin expressing CD8+ T cel.
Figure 5 | | Changes in IFN-g and IL-2 expression in CD8+ T cel.
Figure 5 | | Changes in IFN-g and IL-2 expression in CD8+ T cel.
Conclusion: The changes in the immune characteristics of CD8+ T cells may play a role in the immune tolerance of hepatitis patients after bankruptcy, and the related indicators of activation and killing functions may help to indicate that there may be postpartum hepatitis patien.
Original source: Song A, Liu Y, Cao Z, et .
Clinical Features and T Cell Immune Characteristics of Postpartum Hepatitis Flare in Pregnant Women With HBeAg-Positive Chronic HBV Infecti.
Front Immunol 2022;13 Clinical Features and T Cell Immune Characteristics of Postpartum Hepatitis Flare in Pregnant Women With HBeAg-Positive Chronic HBV Infecti.
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