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    Home > Active Ingredient News > Endocrine System > Front Immunol: Elevated levels of IL-36 in obesity and type 2 diabetes promote adipose tissue inflammation by inducing its own expression and release from adipocytes and macrophages

    Front Immunol: Elevated levels of IL-36 in obesity and type 2 diabetes promote adipose tissue inflammation by inducing its own expression and release from adipocytes and macrophages

    • Last Update: 2022-04-21
    • Source: Internet
    • Author: User
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    Obesity, defined as the excessive accumulation of dysfunctional adipose tissue (AT), is a major global epidemic leading to important physiological and metabolic related dysfunctions, including type 2 diabetes (T2D), cardiovascular disease and cancer


    Interleukin-36 (IL-36) is a cytokine discovered in recent years and plays an important role in the regulation of various inflammatory diseases



    1|T2DIL-36G


    1|T2DIL-36G


    2|IL36GIL36R


    2|IL36GIL36R


    3|(A)IL-36GIL-36R(B)(BCM)IL-36G


    3|(A)IL-36GIL-36R(B)(BCM)IL-36G


    4|(ACM)


    4|(ACM)


    These findings provide the first evidence for the role of IL-36g in regulating chronic inflammation in AT, serving as a link between AT biology and obesity-related comorbidities


    .
    Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages.


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