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Obesity, defined as the excessive accumulation of dysfunctional adipose tissue (AT), is a major global epidemic leading to important physiological and metabolic related dysfunctions, including type 2 diabetes (T2D), cardiovascular disease and cancer
Interleukin-36 (IL-36) is a cytokine discovered in recent years and plays an important role in the regulation of various inflammatory diseases
1|T2DIL-36G
1|T2DIL-36G
2|IL36GIL36R
2|IL36GIL36R
3|(A)IL-36GIL-36R(B)(BCM)IL-36G
3|(A)IL-36GIL-36R(B)(BCM)IL-36G
4|(ACM)
4|(ACM)
These findings provide the first evidence for the role of IL-36g in regulating chronic inflammation in AT, serving as a link between AT biology and obesity-related comorbidities
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Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages.
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