-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Bullous pemphigoid (BP) is a chronic autoimmune skin disease with severe itching more common in the elderly
.
It is characterized by skin urticaria, erythema, or painful blisters, and circulating autoantibodies against the half-chromosomal molecules BP180 and BP230 are localized in the basement membrane region of the skin and in basal keratinocytes
Histopathological examination of BP lesions showed subepidermal blebbing, typically with neutrophilic and eosinophilic infiltration
.
Although the exact mechanism is unclear, it has been established that autoantibodies against BP180 may trigger BP through three pathways
Given their importance in BP disease, these cytokines may be promising targets for the development of new, effective therapeutic strategies for BP
.
Cytokines play a cytokine function by regulating the expression of cytokine proteins and the release of cytokines, regulating the susceptibility of autoimmune diseases
In order to investigate the distribution and clinical significance of cytokine gene polymorphisms in Chinese BP patients, we used a retrospective case-control study to investigate the relationship between various cytokine gene polymorphisms and serum cytokine levels, clinical manifestations and prognosis of patients.
relationship
.
Our goal was to identify the key cytokines most associated with BP and to explore the association of patient characteristics with gene polymorphisms of these cytokines
IL-1a(Rs1800587), IL-1b(rs16944, rs1143627, rs1143634), IL-4(Rs2243250), IL-6(Rs1800795), IL-10(rs1800896, rs1800871, rs1800872), IL-13(rs1800925, rs2000925) ), TNF-a (rs1799964, rs1799964
.
Expression of these cytokines in serum was detected
We found that the serum levels of IL-1 and IL-13 in BP patients were significantly higher than those in controls
.
There were significant differences in the nucleotide ratio/genotype/haplotype frequency/haplotype of IL-13, respectively
BP is associated with IL-13 gene polymorphisms, and the concentration of IL-13 in the blood of BP patients is increased
.
Our results support that IL-13 is involved in the pathogenesis of BP, suggesting that IL-13 may be a potential target and prognostic marker for BP therapy
Source: Wang Y, Mao X, Liu Y, et al.
leave a message here