Front Immunol: Laboratory confirmed potential cross-reactive immunity of MERS-CoV infected patients to COVID -19 infection

Background: More and more experiments have shown that there is a potential cross-reactive immunity between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and previous human coronaviruses
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This study adopts a retrospective cohort study method to explore the relationship between previous Middle East respiratory syndrome coronavirus (MERS-CoV) infection and the risk of SARS-CoV-2 infection, as well as the hospitalization and mortality associated with MERS-CoV and COVID -19 The relationship between

There is a potential cross-reactive immunity between Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and previous human coronaviruses

Method: Starting in March 2020, we prospectively followed two groups of individuals who tested negative for COVID-19 infection
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The first group was previously confirmed to have MERS coronavirus infection and compared with a control group of MERS-negative individuals

Results: A total of 82 (24%) MERS-positive patients and 260 (31%) MERS-negative patients had COVID -19 infection
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The risk of COVID-19 infection in the MERS-positive group was lower than that of the MERS-negative group (risk ratio [RR] 0.

Figure 1 Clinical characteristics of COVID -19 infection subgroups in the cohort
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The blue bar represents the patient’s symptoms, the orange bar represents the presence of complications, and the gray bar represents the patient’s prognosis

Figure 1 Clinical characteristics of COVID -19 infection subgroups in the cohort

Table 1 SARS-CoV-2 infection and mortality measurement in cohort subjects
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Table 1 SARS-CoV-2 infection and mortality measurement in cohort subjects
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Table 2 The risk of MERS infection group relative to SARS-CoV-2 infection, presence of symptoms, hospitalization and death

Table 2 The risk of MERS infection group relative to SARS-CoV-2 infection, presence of symptoms, hospitalization and death

Table 3 Multivariate logistic regression of independent predictors of SARS-CoV-2 infection in the study cohort

Table 3 Multivariate logistic regression of independent predictors of SARS-CoV-2 infection in the study cohort

Figure 2 Cases and deaths based on MERS and COVID-19 infections
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Figure 2 Cases and deaths based on MERS and COVID-19 infections
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Conclusion: Individuals who have previously been infected with MERS-CoV show a cross-reactive immune response to SARS-CoV-2 infection
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Our research shows that compared with MERS-negative patients, patients with MERS coronavirus infection are at higher risk of hospitalization and death associated with new coronary pneumonia

Individuals who have previously been infected with MERS-CoV show a cross-reactive immune response to SARS-CoV-2 infection

Khan AA, Alahmari AA, Almuzaini Y, et al, Potential Cross-Reactive Immunity to COVID-19 Infection in Individuals With Laboratory-Confirmed MERS-CoV Infection: A National Retrospective Cohort Study From Saudi Arabia .

Potential Cross-Reactive Immunity to COVID-19 Infection in Individuals With Laboratory-Confirmed MERS-CoV Infection: A National Retrospective Cohort Study From Saudi Arabia

 

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