Front Immunol: Links between vitamin D status and inflammatory responses in COVID-19 patients

Background: Since 2020, coronavirus disease 2019 (COVID-19), caused by the novel betacoronavirus SARS-CoV-2, has emerged as a pandemic, manifesting asymptomatic to fatal severe acute respiratory syndrome ( variable phenotypes of SARS-CoV-2)

Coronavirus disease 2019 (COVID-19), caused by the novel beta-coronavirus SARS-CoV-2, has emerged as a pandemic, manifesting from asymptomatic to fatal severe acute respiratory syndrome (SARS-CoV-2) variable phenotype

Results: Low vitamin D (25-OHD≤20 ng/ml) occurred in 65% of patients, IL-6 [20.

Figure 1 Inflammatory markers in patients with 25-OHD level > 20 ng/ml and patients with 25-OHD level ≤ 20 ng/ml [(A) IL-6, (B) CRP, (C) TNF-α, (D) ) D-dimer, (E) IL-10] difference

Figure 1 Inflammatory markers in patients with 25-OHD level > 20 ng/ml and patients with 25-OHD level ≤ 20 ng/ml [(A) IL-6, (B) CRP, (C) TNF-α, (D) ) D-dimer, (E) IL-10] difference

Figure 2: Inflammatory markers in SARS-CoV-2 patients [(A) IL-6, (B) CRP, (C) TNF-α, (D) D-dimer, (E) IL-10] and 25OHD horizontal correlation

Figure 2: Inflammatory markers in SARS-CoV-2 patients [(A) IL-6, (B) CRP, (C) TNF-α, (D) D-dimer, (E) IL-10] and 25OHD horizontal correlation

Figure 3 Differences in the proportion of patients with vitamin D deficiency (25OHD level ≥20 ng/ml) in patients with arterial partial pressure of oxygen/oxygen saturation (PaO2/FiO2) <200, 201-300, and ≤300 mmHg

Figure 3 Differences in the proportion of patients with vitamin D deficiency (25OHD level ≥20 ng/ml) in patients with arterial partial pressure of oxygen/oxygen saturation (PaO2/FiO2) <200, 201-300, and ≤300 mmHg

Figure 4 Differences in 25OHD levels between surviving and non-surviving patients * ** p < 0.

Figure 4 Differences in 25OHD levels between surviving and non-surviving patients * ** p < 0.

The relationship between 25-OHD levels and inflammatory markers suggests that vitamin D status needs to be considered in the management of these patients

Is There a Crucial Link Between Vitamin D Status and Inflammatory Response in Patients With COVID-19?

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