Front Immunol: Targeted stem cells can be used to regulate inflammatory responses.

October 4, 2020 /---, also known as gum disease, is a serious infectious disease.
if left uncensioned, periodontage can damage the jaw and cause teeth to fall out.
the disease is also associated with a higher risk of diabetes and cardiovascular disease.
current treatment for periodontary disease includes opening infected gum valves and adding bone implants to strengthen teeth.
but in a new study recently published in the journal Frontiers in Immunology, scientists have found that a specific type of molecule may stimulate stem cell regeneration, reversing inflammation caused by periodontical disease.
findings could lead to the development of new therapies to treat a variety of systemic diseases characterized by inflammation in the body.
for the study, Dr. Alpdogan Kantarci and his student, Dr. Emmanuel Albuquerque, removed stem cells from their previously pulled wisdom teeth and placed them in petri dishes.
, the researchers created a simulated inflammatory periodontological disease environment in a petri dish.
, they added two specific types of synthetic molecules, called Marinen-1 and Resolvin-E1.
have found that Mar1 and RvE1 stimulate stem cell regeneration even under inflammatory conditions.
"Both Maresin-1 and Resolvin-1 have reprogrammed human stem cells, suggesting that even responding to inflammation may enhance the ability of stem cells to regenerate easily," Dr Kantarci said.
important to this finding because it allows scientists to identify specific protein pathways associated with inflammation.
same protein pathways are consistent in many systemic diseases, including periodontology, diabetes, heart disease, dementia, and obesity.
Kantarci said:
I now understand how these molecules stimulate stem cell differentiation in different tissues and reverse inflammation at critical moments, so the mechanisms we have identified could one day be used to build complex organs."
" (bioon.com) Source: Researchers show how to change the stem cell to response may reverse periodontal disease Original source: Emmanuel Albuquerque-Souza et al, Maresin-1 and Resolvin E1 Promoter Regenerative Properties of Periodontal Liga Stems Cells Under UnderIngs, Conditions in FrontierLogy (2020). DOI: 10.3389/fimmu.2020.585530.