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    Home > Active Ingredient News > Immunology News > Front Immunol: Targeting FcRN: A New Way to Treat Pemphigus

    Front Immunol: Targeting FcRN: A New Way to Treat Pemphigus

    • Last Update: 2021-10-20
    • Source: Internet
    • Author: User
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    , Keratinocytes adhere to desmosomes on the skin and mucous membranes, leading to acantholysis


    , Free Ig is sorted into lysosomes and degraded


    Schematic illustration of the effect of inhibiting FcRN on pemphigus disease activity


    Schematic diagram of the effect of inhibiting FcRN on pemphigus disease activity



    ALXN1830 reduced the levels of IgG and IgGIC in all patients



    Therefore, it may be contraindicated for pregnant women to use the drug


    The status of FcRN inhibitors in the existing treatment options for pemphigus



    Original source:

    Bosch-Amate X, Iranzo P, Ivars M, Targeting the FcRn: A Novel Approach to the Treatment of Pemphigus, Front Immunol 2021;12

     



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