Front Immunol: The relationship between nutritional immunity, zinc adequacy and COVID-19 mortality in similar populations in European society

 

Background: Zinc (Zn) is a key trace element that is redox neutral and plays an important role in immunity and health
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Worldwide, for the so-called "zinc deficiency" people and COVID-19 patients, it is recommended to enhance immunity through healthy diet or zinc supplementation

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Zinc (Zn) is a key trace element that is redox neutral and plays an important role in immunity and health to supplement the presumption of zinc in infection and other immune and oxidative stress-related conditions/pathologies related to COVID-19 Protection During infection, as part of the "nutritional immunity", the level of free zinc will decrease, which can lead to the growth and replication of pathogens and the consequent inflammatory damage

Results: The population's zinc nutrition status was positively correlated with the mortality rate of new coronary pneumonia [r(23): 0.
7893~0.
6849, p value<0.
0003] and incidence rate [r(23): 0.
8084~0.
5658; p value<0.
005] .
The observed results are contrary to the prediction that zinc sufficient has a protective effect on new coronary pneumonia .

The population's zinc nutrition status is positively correlated with the mortality and morbidity of new coronary pneumonia

The zinc sufficiency of European populations with similar figures is associated with COVID-19 mortality
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Study population: (A) Zinc adequacy estimate; (B, C) deaths and cases/million (April 26)

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The zinc sufficiency of European populations with similar figures is associated with COVID-19 mortality

Table Coronavirus disease (COVID-19) mortality and morbidity and the correlation analysis of population zinc deficiency

Table Coronavirus disease (COVID-19) mortality and morbidity and the correlation analysis of population zinc deficiency

Conclusion: Include the data of patients with adverse events for controlled trials or retrospective analysis to correctly guide the practice of zinc supplementation for new coronary pneumonia

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Include the data of patients with adverse events for controlled trials or retrospective analysis to correctly guide the practice of zinc supplementation for new coronary pneumonia

Singh S, Diwaker A, Singh BP,et al, Nutritional Immunity, Zinc Sufficiency, and COVID-19 Mortality in Socially Similar European Populations .

Front Immunol 2021;12

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