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Front Oncol: Efficacy of salvage surgery for patients with recurrent nasopharyngeal carcinoma: a meta-analysis

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Nasopharyngeal carcinoma is a malignant tumor that occurs in the head and neck, originating from the epithelial cells of the nasopharyngeal area
.

The main treatment strategy for nasopharyngeal carcinoma is radiotherapy with or without chemotherapy

Nasopharyngeal carcinoma is a malignant tumor that occurs in the head and neck, originating from the epithelial cells of the nasopharyngeal area

Finally, 21 articles were screened out, 17 of which had a sample size greater than 10, and were included in the meta-analysis
.

10 articles provide detailed survival data

Finally, 21 articles were screened out, 17 of which had a sample size greater than 10, and were included in the meta-analysis

The 2-year OS, 5-year OS, and 2-year DFS of rNPC patients with or without adjuvant therapy after surgery were 71% (95% CI, 62%-80%, I ² = 83.

Surgical treatment prognosis

In the subgroup analysis, the 2-year OS rate of patients undergoing surgery alone (72%, 95% CI, 61%-83%, I ² = 86.
3%, p <0.
05) was better than surgery + adjuvant therapy patients (64% , 95% CI, 55%-73%, I ² = 0.
00%, p = 0.
641)
.

The 5-year OS rate in the postoperative adjuvant therapy group was 44% (95% CI, 35%-52%, I ² = 0.

In the subgroup analysis, the 2-year OS rate of patients undergoing surgery alone (72%, 95% CI, 61%-83%, I ² = 86.

Subgroup analysis

The study further compared patients treated with surgery alone.
The 5-year OS in the open surgery group was 77.
0%, the endoscopic surgery group was 82.
5% (p>0.
05); the 2-year DFS in the open surgery group was 85.
0%, and the endoscopic surgery group was 2 years The DFS is 72.
5% (p>0.
05)
.

For patients undergoing open surgery, the 5-year OS rate of postoperative adjuvant therapy patients was 35.

The study further compared patients treated with surgery alone.

Resection margin status, recurrence T stage, and adjuvant therapy affect the survival and prognosis of patients

Prognostic factors

Prognostic related factors Prognostic related factors

In summary, this meta-analysis shows that salvage surgery for patients with recurrent nasopharyngeal cancer is beneficial to survival
.

Accurate assessment of tumor recurrence and staging and selection of appropriate surgical methods are the keys to success

In summary, this meta-analysis shows that salvage surgery for patients with recurrent nasopharyngeal cancer is beneficial to survival
.
Accurate assessment of tumor recurrence and staging and selection of appropriate surgical methods are the keys to success
.
More randomized controlled studies are needed in the later period to further confirm
.
The meta-analysis showed that salvage surgery for patients with recurrent nasopharyngeal cancer is beneficial to survival
.
Accurate assessment of tumor recurrence and staging and selection of appropriate surgical methods are the keys to success
.
More randomized controlled studies are needed in the later period to further confirm
.
The meta-analysis showed that salvage surgery for patients with recurrent nasopharyngeal cancer is beneficial to survival
.
Accurate assessment of tumor recurrence and staging and selection of appropriate surgical methods are the keys to success
.
More randomized controlled studies are needed in the later period to further confirm
.

Original source:

Feng Y, Dai Z, Yan R, Li F, Zhong X, Ye H, Chen C, Fan S, Qing C, Pan Y and Sun H (2021) Outcomes of Recurrent Nasopharyngeal Carcinoma Patients Treated With Salvage Surgery: A Meta-Analysis .
Front.
Oncol.
11:720418.
doi: 10.
3389/fonc.
2021.
720418

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