Front Oncol: The best type of surgery and adjuvant treatment for stage T1N0M0 lung large cell neuroendocrine carcinoma

The appropriate treatment strategy for stage T1N0M0 lung large cell neuroendocrine carcinoma (LCNEC) has not been elucidated
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A team from Sun Yat-sen University Cancer Center has carried out relevant research to evaluate the efficacy of different surgical types and adjuvant treatments for patients with stage T1N0M0 LCNEC

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The appropriate treatment strategy for stage T1N0M0 lung large cell neuroendocrine carcinoma (LCNEC) has not been elucidated

The researchers screened the LCNEC patients diagnosed with stage T1N0M0 from 2004 to 2016 in the SEER database

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The researchers screened the LCNEC patients diagnosed with stage T1N0M0 from 2004 to 2016 in the SEER database

During the period 2004-201, a total of 425 patients were included in this study, of which 55.

Among the 425 patients, most patients underwent surgery (lobectomy: 59.

Compared with non-surgical patients, patients with surgical treatment had longer OS (P=0.

The type of surgery affects OS

The type of surgery affects OS

The study further analyzed the impact of adjuvant chemotherapy and radiotherapy on survival

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The study further analyzed the impact of adjuvant chemotherapy and radiotherapy on survival

The effect of adjuvant treatment on OS

The effect of adjuvant treatment on OS

Univariate analysis showed that younger age, surgical resection and regional lymph node dissection were associated with better prognosis (all p<0.

05)

Univariate analysis showed that younger age, surgical resection and regional lymph node dissection were associated with better prognosis (all p<0.

Prognostic factors

Prognostic related factors Prognostic related factors

In summary, studies have shown that lobectomy and regional lymph node dissection are associated with a significant increase in survival

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Extensive regional lymph node dissection (4 or more) is more effective than 1-3 lymph node dissection to prolong survival
.
For tumors smaller than 2 cm, adjuvant chemotherapy has nothing to do with prolonging survival, while for tumors of 2 to 3 cm, it may prolong survival
.

In summary, studies have shown that lobectomy and regional lymph node dissection are associated with a significant increase in survival
.
Extensive regional lymph node dissection (4 or more) is more effective than 1 to 3 lymph node dissection to prolong survival
.
For tumors smaller than 2 cm, adjuvant chemotherapy has nothing to do with prolonging survival, while for tumors of 2 to 3 cm, it may prolong survival
.
Studies have shown that lobectomy and regional lymph node dissection are associated with a significant increase in survival
.
Extensive regional lymph node dissection (4 or more) is more effective than 1-3 lymph node dissection to prolong survival
.
For tumors smaller than 2 cm, adjuvant chemotherapy has nothing to do with prolonging survival, while for tumors of 2 to 3 cm, it may prolong survival
.
Studies have shown that lobectomy and regional lymph node dissection are associated with a significant increase in survival
.
Extensive regional lymph node dissection (4 or more) is more effective than 1-3 lymph node dissection to prolong survival
.
For tumors smaller than 2 cm, adjuvant chemotherapy has nothing to do with prolonging survival, while for tumors of 2 to 3 cm, it may prolong survival
.

Original source:

Original source:

Peng K, Cao H, You Y, et al(2021) Optimal Surgery Type and Adjuvant Therapy for T1N0M0 Lung Large Cell Neuroendocrine Carcinoma.
Front.
Oncol.
11:591823.
doi: 10.
3389/fonc.
2021.
591823

Peng K, Cao H, You Y , et al (2021) Optimal Surgery Type and Adjuvant Therapy for T1N0M0 Lung Large Cell Neuroendocrine Carcinoma Front Oncol 11:.
.
.
591823.
doi: 10.
3389 / fonc.
2021.
591823 in this message