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    Home > Active Ingredient News > Antitumor Therapy > Front Oncol: The combination of T staging and the number of pathological lymph nodes provides a better prognostic identification for early cervical cancer with lymph node involvement

    Front Oncol: The combination of T staging and the number of pathological lymph nodes provides a better prognostic identification for early cervical cancer with lymph node involvement

    • Last Update: 2021-11-13
    • Source: Internet
    • Author: User
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    Under the new FIGO 2018 staging system, stage I and stage II cervical cancer with pelvic and / or para-aortic lymph node (LN) metastasis is elevated to stage IIIC , and radical radiotherapy and chemotherapy are recommended .
    But in this group of patients, the results are heterogeneous .
    Therefore, the team from Ruijin Hospital of Shanghai Jiaotong University conducted a retrospective study to assess the heterogeneity of these patients and tried to provide a more detailed classification to reflect the prognosis and guide treatment .
    At the same time, the efficacy and toxicity of sequential radiotherapy and chemotherapy after surgery were also evaluated .
    Related results were published in Frontiers in Oncology journal .

    Under the new FIGO 2018 staging system, stage I and stage II cervical cancers with pelvic and / or para-aortic lymph node (LN) metastasis are upgraded to stage IIIC , and radical radiotherapy and chemotherapy are recommended .


    But in this group of patients, the results are heterogeneous .
    Therefore, the team from Ruijin Hospital of Shanghai Jiaotong University conducted a retrospective study to assess the heterogeneity of these patients and tried to provide a more detailed classification to reflect the prognosis and guide treatment .
    At the same time, the efficacy and toxicity of sequential radiotherapy and chemotherapy after surgery were also evaluated .
    Related results were published in Frontiers in Oncology journal .
    Under the FIGO 2018 staging system, stage I and stage II cervical cancer with pelvic and / or para-aortic lymph node (LN) metastasis is elevated to stage IIIC .
    Radical chemotherapy and radiotherapy are recommended .
    Relevant results of Ruijin Hospital were published in Frontiers in Oncology


    This study retrospectively analyzed patients with early cervical cancer with LN involvement undergoing sequential radiotherapy and chemotherapy after radical hysterectomy
    .


    Perform survival analysis to determine prognostic factors


    This study retrospectively analyzed patients with early cervical cancer with LN involvement undergoing sequential radiotherapy and chemotherapy after radical hysterectomy


    After a median follow-up of 40 (5-132) months, 64 (26.


    OS and DFS

    OS and DFS  OS and DFS

    In terms of predicting the factors of DFS , we observed histology, tumor size, T stage at diagnosis , pT stage, parauterine infiltration status, borderline status, metastatic LN burden, whether to start adjuvant chemotherapy, and whether to start new treatment in univariate analysis.
    adjuvant chemotherapy with DFS related
    .


    Multivariate analysis showed that only non- SCC, T2, ≥3 months PLN and neoadjuvant chemotherapy and poorer DFS related


    In terms of predicting the factors of DFS , we observed histology, tumor size, T stage at diagnosis , pT stage, parauterine infiltration status, borderline status, metastatic LN burden, whether to start adjuvant chemotherapy, and whether to start new treatment in univariate analysis.


    Through univariate analysis, there is a significant difference between DFS and OS according to T period


    The number of pLNs is related to OS.


                                             Subgroup analysis

                                             Subgroup analyzes                                          Subgroup analyzes

    T1N <pLN.
    3
    the OS group with other groups were significantly different, and T2N , T1N ≧ 3 pLN , T2N ≧ 3 pLN patients with similar prognosis group
    .


    The treatment failure rates in the T1N <3 pLN group and T2N <3 pLN /T1-2 N ≥ 3 pLN group were 11.


    T1N <pLN.


    Multivariate results showed that non-squamous cell carcinoma, neoadjuvant chemotherapy, and T2N + / T1N ≥ 3PLN were negative prognostic factors for OS


              Multifactor OS related factors

             Multi-factor OS-related factors Multi-factor OS-related factors

     About 1.
    5% of patients stopped radiotherapy, 14.
    1% of patients had G3-4 hematological toxicity during radiotherapy ; 1.
    7% had G2-3 lower extremity edema, and 2.
    9% had severe nephrotoxicity
    .

     About 1.
    5% of patients stopped radiotherapy, 14.
    1% of patients had G3-4 hematological toxicity during radiotherapy ; 1.
    7% had G2-3 lower extremity edema, and 2.
    9% had severe nephrotoxicity
    .


    About 1.
    5% of patients stopped radiotherapy, 14.
    1% of patients had G3-4 hematological toxicity during radiotherapy ; 1.
    7% had G2-3 lower extremity edema, and 2.
    9% had severe nephrotoxicity .
     

    In summary, studies have shown that simple lymph node involvement is not enough to predict the survival of early cervical cancer as the only pathological factor
    .
    Combining tumor and lymph node sub-classification provides better prognostic identification
    .

    In summary, studies have shown that simple lymph node involvement is not enough to predict the survival of early cervical cancer as the only pathological factor
    .
    Combining tumor and lymph node sub-classification provides better prognostic identification
    .
    In summary, studies have shown that simple lymph node involvement is not enough to predict the survival of early cervical cancer as the only pathological factor
    .
    Studies have shown that simple lymph node involvement is not enough to predict the survival of early cervical cancer as the only pathological factor
    .
    Studies have shown that simple lymph node involvement is not enough to predict the survival of early cervical cancer as the only pathological factor
    .
    Combining tumor and lymph node sub-classification provides better prognostic identification
    .
    Combining tumor and lymph node sub-classification provides better prognostic identification
    .

    Original source:

    Original source:

    Bai Y, Rong L, Hu B, Ma X, Wang J and Chen H (2021) The Combination of T Stage and the Number of Pathologic Lymph Nodes Provides Better Prognostic Discrimination in Early-Stage Cervical Cancer With Lymph Node Involvement.
    Front.
    Oncol .
    11:764065.
    doi: 10.
    3389/fonc.
    2021.
    764065

    Bai Y, Rong L, Hu B, Ma X, Wang J and Chen H (2021) The Combination of T Stage and the Number of Pathologic Lymph Nodes Provides Better Prognostic Discrimination in Early-Stage Cervical Cancer With Lymph Node Involvement.
    Front.
    Oncol .
    11:764065.
    doi: 10.
    3389/fonc.
    2021.
    764065 leave a message here
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