Front Oncol: The effect of partial ureterectomy + adjuvant radiotherapy for distal ureteral urothelial carcinoma (UC)

The gold standard treatment for distal ureteral urothelial carcinoma (UC) is radical nephroureterectomy (RNU) and bladder sleeve removal
.

But partial ureterectomy (PU) is also a viable option, especially in patients with solitary kidney or bilateral ureteral cancer or chronic renal insufficiency

The gold standard treatment for distal ureteral urothelial carcinoma (UC) is radical nephroureterectomy (RNU) and bladder sleeve removal

The study analyzed the clinical data of a total of 221 T3 or G3 patients receiving PU or RNU in the hospital from January 2008 to September 2019
.

Among them, 17 cases were treated with PU+ART, 72 cases were treated with PU alone, and 132 cases were treated with radical nephroureterectomy (RNU)

The study analyzed the clinical data of a total of 221 T3 or G3 patients receiving PU or RNU in the hospital from January 2008 to September 2019

The median age of the patients was 68 years (IQR 62-76), and the median follow-up time was 43 months (IQR 28-67)

Clinical features

Clinical features Clinical features

The 5-year RFS, MFS, CSS and OS rates in the PU+ART group were 67.
6%, 73.
2%, 70.
7% and 70.
7%, respectively
.

The 5-year RFS, MFS, CSS, and OS rates in the PU-only group were 39.

The 5-year RFS, MFS, CSS and OS rates in the PU+ART group were 67.

Prognosis

PrognosisPrognosis

Compared with the pure PU group, PU+ART significantly improved the 5-year RFS rate of patients (67.
6% vs.
39.
5%, HR: 2.
431, 95%CI 1.
210-4.
883, p=0.
039)
.

However, the 5-year RFS difference between the PU+ART group and the RNU group was not statistically significant (67.

Compared with the pure PU group, PU+ART significantly improved the 5-year RFS rate of patients (67.

Because the difference in survival outcome only exists in the RFS of the PU+ART group and the PU group

              Univariate and multivariate analysis

              Univariate and multivariate analysis Univariate and multivariate analysis

In summary, the study shows that for patients with T3 or G3 distal ureteral carcinoma, adjuvant radiotherapy can significantly prolong the recurrence-free survival compared with simple partial ureterectomy
.

However, there was no significant difference in survival rates between PU+ART and radical nephroureterectomy

In summary, the study shows that for patients with T3 or G3 distal ureteral carcinoma, adjuvant radiotherapy can significantly prolong the recurrence-free survival compared with simple partial ureterectomy
.
However, there was no significant difference in survival rates between PU+ART and radical nephroureterectomy
.
The study showed that for patients with T3 or G3 distal ureteral urothelial carcinoma, compared with simple partial ureterectomy, adjuvant radiotherapy can significantly prolong the recurrence-free survival
.
However, there was no significant difference in survival rates between PU+ART and radical nephroureterectomy
.
The study showed that for patients with T3 or G3 distal ureteral urothelial carcinoma, compared with simple partial ureterectomy, adjuvant radiotherapy can significantly prolong the recurrence-free survival
.
However, there was no significant difference in survival rates between PU+ART and radical nephroureterectomy
.

Original source:

Original source:

Li Hz, Li X, Gao Xs, Qi X, Ma MW and Qin S (2021) Oncological Outcomes of Adjuvant Radiotherapy for Partial Ureterectomy in Distal Ureteral Urothelial Carcinoma Patients.
Front.
Oncol.
11:699210.
doi: 10.
3389/fonc.
2021.
699210

Li Hz, Li X, Gao Xs, Qi X, Ma MW and Qin S (2021) Oncological Outcomes of Adjuvant Radiotherapy for Partial Ureterectomy in Distal Ureteral Urothelial Carcinoma Patients.
Front.
Oncol.
11:699210.
doi: 10.
3389/fonc.
2021.
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