 Home > Active Ingredient News > Digestive System Information > Front Oncol: The relationship between preoperative radiotherapy (RT) and CEA level before treatment with the prognosis of patients with locally advanced rectal cancer (LARC)

Front Oncol: The relationship between preoperative radiotherapy (RT) and CEA level before treatment with the prognosis of patients with locally advanced rectal cancer (LARC)

 Last Update: 2021-10-20
 Source: Internet
 Author: User

Tags

pk pd studies

2 cyclohexen 1

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Preoperative radiotherapy, whether it is long course radiotherapy (LCRT) or short course radiotherapy (SCRT), is the standard neoadjuvant treatment strategy for the treatment of locally advanced rectal cancer (LARC)

The study collected relevant data of LARC patients diagnosed from 2011 to 2015 in the SEER database, and divided them into surgical treatment group (S) and preoperative radiotherapy continuous surgical treatment group ((RT+S) according to the inclusion criteria

A total of 2760 patients were eligible, including 350 (12.

Before PSM, the 1, 3, and 4-year CSS of the RT+S and S groups were 98.

Before PSM, the 1, 3, and 4-year CSM of the two groups were 1.

In the matched cohort, 420 patients had normal CEA levels, including 213 patients in the S group and 207 patients in the RT+S group

In the matched cohort, 242 patients had elevated CEA levels before treatment, including 118 in the S group and 124 in the RT+S group

CEA level after PSM affects
CSM
CEA level
after PSMaffects CSMCEA level after PSMaffects CSMCEA level after PSM affects CSM

In addition, a multivariate analysis of the subgroup with elevated CEA showed that preoperative radiotherapy was an independent protective factor for CSS and CSM (CSS: HR = 0.
36, 95% CI = 0.
15 0.
83, p = 0.
017; CSM: HR = 0.
41, 95% CI = 0.
18 0.
94, p = 0.
036)
.
In addition, a multivariate analysis of the subgroup with elevated CEA showed that preoperative radiotherapy was an independent protective factor for CSS and CSM (CSS: HR = 0.
36, 95% CI = 0.
15 0.
83, p = 0.
017; CSM: HR = 0.
41, 95% CI = 0.
18 0.
94, p = 0.
036)
.
In addition, a multivariate analysis of the subgroup with elevated CEA showed that preoperative radiotherapy was an independent protective factor for CSS and CSM (CSS: HR = 0.
36, 95% CI = 0.
15 0.
83, p = 0.
017; CSM: HR = 0.
41, 95% CI = 0.
18 0.
94, p = 0.
036)
.

Factors related to CSS and CSM in patients with elevated CEA

In summary, studies have shown that the level of CEA before treatment is considered a potential marker for screening LARC patients who have obtained long-term survival from preoperative radiotherapy
.
Studies have shown that the level of CEA before treatment is considered a potential marker for screening LARC patients who have obtained long-term survival from preoperative radiotherapy
.
Studies have shown that the level of CEA before treatment is considered a potential marker for screening LARC patients who have obtained long-term survival from preoperative radiotherapy
.

Original source:

Wang L, Zhong X, Lin H, Shao L, Chen G and Wu J (2021) The Correlation Between Survival Benefit of Preoperative Radiotherapy and Pretreatment Carcinoembryonic Antigen Level in Locally Advanced Rectal Cancer.
Front.
Oncol.
11:735882.
doi: 10.
3389 /fonc.
2021.
735882

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.