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    Home > Active Ingredient News > Antitumor Therapy > Front Oncol: Weekly PCC regimen (paclitaxel + carboplatin + cetuximab) can be used for patients who are not suitable for EXTREME regimen to treat recurrent and/or metastatic head and neck squamous cell carcinoma (R/M-HNSCC)

    Front Oncol: Weekly PCC regimen (paclitaxel + carboplatin + cetuximab) can be used for patients who are not suitable for EXTREME regimen to treat recurrent and/or metastatic head and neck squamous cell carcinoma (R/M-HNSCC)

    • Last Update: 2021-11-12
    • Source: Internet
    • Author: User
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    For most patients with recurrent and / or metastatic head and neck squamous cell carcinoma ( R/M-HNSCC ), chemotherapy is the main treatment
    .


    For more than ten years, cetuximab combined with platinum - fluorouracil regimen (EXTREME) has been the standard treatment regimen


    For most patients with recurrent and / or metastatic head and neck squamous cell carcinoma ( R/M-HNSCC ), chemotherapy is the main treatment


    The study reviewed the medical records of all patients who received paclitaxel, carboplatin, and cetuximab (PCC) at the institution .
    The selection criteria are : first - line R/M-HNSCC treatment of oral cavity, oropharynx, hypopharynx or larynx is not suitable for local treatment, not suitable for cisplatin and / or 5-FU , ECOG-PS: 0-2 .
    PCC includes paclitaxel 80 mg/m2, carboplatin AUC 2 and cetuximab.
    The initial dose is 400 mg/m2, and then 250 mg/m2.
    It is administered for a total of 16 cycles per week.
    Cetuximab is maintained .
    The primary endpoint is overall survival (OS), and the secondary endpoints are overall response rate (ORR), progression-free survival (PFS) and safety .

    The study reviewed the medical records of all patients who received paclitaxel, carboplatin, and cetuximab (PCC) at the institution .


    The selection criteria are : first - line R/M-HNSCC treatment of oral cavity, oropharynx, hypopharynx or larynx is not suitable for local treatment, not suitable for cisplatin and / or 5-FU , ECOG-PS: 0-2 .
    PCC includes paclitaxel 80 mg/m2, carboplatin AUC 2 and cetuximab.
    The initial dose is 400 mg/m2, and then 250 mg/m2.
    It is administered for a total of 16 cycles per week.


    2010 years .


    Twenty-nine patients (48%) had an ECOG-PS of 0-1 at the beginning of treatment, and 31 patients (52%) had an ECOG-PS of 2


    Thirty patients (50%) showed grade III-IV toxicity


    toxicity

    Toxicity   toxicity

    The ORR of PCC treatment was 43.


    3% (95% CI: 30.


    The ORR of PCC treatment was 43.


                  Efficacy evaluation

                  Efficacy assessment Efficacy assessment

    The median follow-up time was 35.
    7 months (IQR 28.
    6-48.
    8), the median OS was 11.
    7 months (95% CI: 7.
    5-14.
    8), and the median PFS was 5.
    8 months (95% CI: 4.
    5-7.
    2)
    .

    The median follow-up time was 35.
    7 months (IQR 28.
    6-48.
    8), the median OS was 11.
    7 months (95% CI: 7.
    5-14.
    8), and the median PFS was 5.
    8 months (95% CI: 4.
    5-7.
    2)
    .


    The median follow-up time was 35.


               PFS

               PFS  PFS

    Among patients with an ECOG-PS of 0-1 (ie 29 patients), the median OS was 14.
    8 months (95% CI: 12.
    2-21.
    7), and the median PFS was 7.
    1 months (95% CI: 6.
    3-9.
    0 Month)
    .


    The median OS of 2 patients with ECOG-PS (ie 31 patients) was 7.


    Among patients with an ECOG-PS of 0-1 (ie 29 patients), the median OS was 14.


                 OS

                 OS  OS

    In summary, studies have shown that for R/M-HNSCC that is not suitable for EXTREME treatment, the weekly PCC regimen is an optional regimen
    .

    In summary, studies have shown that for R/M-HNSCC
    that is not suitable for EXTREME treatment, the weekly PCC regimen is an optional regimen .
    In summary, the research shows that the research shows that it is not suitable, and the research shows that it is not suitable for EXTREME treatment.
    For R/M-HNSCC
    that is not suitable for EXTREME treatment, the PCC program of weekly treatment is an optional program .
    R/M-HNSCC treated with EXTREME regimen, PCC regimen with weekly treatment is an optional regimen
    .

    Original source:

    Original source:

    Carinato H, Burgy M, Ferry R, ​​et al.
    (2021) Weekly Paclitaxel, Carboplatin, and Cetuximab as First-Line Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma for Patients Ineligible to Cisplatin-Based Chemotherapy: A Retrospective Monocentric Study in 60 Patients.
    Front.
    Oncol.
    11:714551.
    doi: 10.
    3389/fonc.
    2021.
    714551

    Carinato H, Burgy M, Ferry R, ​​et al.
    (2021) Weekly Paclitaxel, Carboplatin, and Cetuximab as First-Line Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma for Patients Ineligible to Cisplatin-Based Chemotherapy: A Retrospective Monocentric Study in 60 Patients.
    Front.
    Oncol.
    11:714551.
    doi: 10.
    3389/fonc.
    2021.
    714551 Carinato H, Burgy M, Ferry R, ​​et al.
    (2021) Weekly Paclitaxel, Carboplatin, and Cetuximab as First-Line Treatment of Recurrent and / or Metastatic Squamous Head and Neck for Patients Ineligible Journal of the Cell-Based to Cisplatin Chemotherapy: A the Retrospective .
    .
    Monocentric Study in Patients 60 Front Oncol.
    11:.
    714 551 DOI:.
    10.
    3389 / fonc.
    2021.
    714551 in this message
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