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BACKGROUND: The etiology and pathogenesis of rheumatoid arthritis (RA) have not been fully elucidated, and traditional drugs for RA have relatively large adverse reactions
.
Therefore, it is particularly necessary to develop traditional Chinese medicine prescriptions as supplementary and alternative medicines for RA treatment
Rheumatoid Arthritis (RA) Rheumatoid Arthritis (RA)
The traditional Chinese medicine compound Longteng Decoction (LTD) is anempirical formula for the treatment of rheumatoid arthritis in Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine , and has been widely used in clinical practice
.
Composition: Chuanshanlong 50 g, Qingfeng rattan 25 g, honeysuckle rattan 30 g, luoshi rattan 30 g, Artemisia annua 25 g, white peony root 25 g
Longteng Decoction (LTD)Longteng Decoction (LTD) Experience Prescription Experienced Prescription Longteng Decoction uses a lot of vine drugs
Although the efficacy of LTD in the treatment of rheumatoid arthritis is very good, there is a lack of basic experimental research, and its specific mechanism of regulating the immune response network and promoting the resolution of synovial inflammation is still unclear
.
.
Objective: To explore whether LTD can promote the resolution of RA synovial inflammation by regulating the immune response mechanism of ILC2
.
Methods: According to the literature description, a collagen-induced (CIA) arthritis mouse model was constructed, and then LTD (27.
75 g/kg/d) was administered orally for 28 days
.
After boosting the immunization, the sagittal plane of the hindlimb radius of the mice was taken every 7 days, and the thickness of the hindlimb metatarsal joint of the mice was measured with a vernier caliper; the CIA arthritis severity score was performed every 7 days
Collagen Inducible (CIA) Collagen Inducible (CIA)
The right hind limbs of all mice were taken for HE staining , TRAP staining and Safranin O staining , respectively, to observe the histopathological changes of synovial inflammation, cartilage destruction and bone erosion and to evaluate and score
.
The contents of F4/80, CD206 and iNOS2 were detected by immunofluorescence
HE staining HE staining TRAP staining TRAP staining Safranin O staining Safranin O staining Immunofluorescence immunofluorescence ELISA kit ELISA kit
Results: After the intervention, the joint swelling, synovial inflammatory infiltration and articular cartilage destruction were alleviated
in CIA mice .
The proliferation and differentiation of Th17 inflammatory cells and the secretion of pro-inflammatory cytokines IL-17 and IFN-γ were inhibited
Joint swelling, synovial inflammatory infiltration and articular cartilage destruction were reduced.
Effective Chinese medicine formula Effective Chinese medicine formula reduces joint inflammation and swelling in CIA mice, inhibits inflammatory infiltration of synovial tissue, and relieves cartilage damage.
Source:
Zhang H, Liu J, Zhang P, et al.
Zhang H, Liu J, Zhang P, et al.
(2021).
Herbal Formula Longteng Decoction Promotes the Regression of Synovial Inflammation in Collagen-Induced Arthritis Mice by Regulating Type 2 Innate Lymphocytes.
Frontiers in pharmacology, 12, 778845.
https:/ /doi.
org/10.
3389/fphar.
2021.
778845 Leave a message here
