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Aging causes changes in brain function and structure, such as cognitive decline , and research suggests that brain aging may occur during the initial stages of neurodegeneration .
An important feature of human biology is that in almost all countries , women live longer than men .
In order to detect preclinical stages of disease development in patients of different genders , it is necessary to capture subtle abnormalities that deviate from healthy states, and it is important to have prior knowledge of healthy brain morphology and activity in samples of different genders .
An important feature of human biology is that in almost all countries , women live longer than men .
In order to detect preclinical stages of disease development in patients of different genders , it is necessary to capture subtle abnormalities that deviate from healthy states, and it is important to have prior knowledge of healthy brain morphology and activity in samples of different genders .
Positron Emission Tomography (PET ) brain imaging is a functional neuroimaging method that can noninvasively reflect glucose metabolism in vivo
.
An early study using FDG-PET showed that women have a higher rate of overall brain glucose metabolism than men
Positron Emission Tomography (PET ) brain imaging is a functional neuroimaging method that can noninvasively reflect glucose metabolism in vivo
Research result
Research result
1.
Subject characteristics1.
Subject characteristics
The authors recruited 344 healthy volunteers, including 217 males and 127 females (age range: 40-89 years)
.
All subjects underwent fluoro-18 fluorodeoxyglucose ( 18F-FDG ) positron emission tomography ( PET )
The authors recruited 344 healthy volunteers, including 217 males and 127 females (age range: 40-89 years)
Table 1 Subject characteristics
Table 1 Subject characteristics
2.
Men and women have inconsistent changes in brain metabolism2.
Research has shown that metabolism in the cerebellum of women is significantly reduced, but not in men
Figure 1 Metabolic changes in the male brain
Figure 1 Metabolic changes in the male brainFigure 2 Changes in female brain regions
Figure 2 Changes in female brain regions
3.
Differences in metabolism between men and women before
Differences in metabolism between men and women before
The authors found that brain metabolism in the caudate nucleus decreased to varying degrees in both the male 60-year-old group and the 70-year-old group, while the occipital region of the female 60-year-old group showed a specific decline
.
The age-related areas of increased FDG uptake were significantly different in male and female subjects
The authors found that brain metabolism in the caudate nucleus decreased to varying degrees in both the male 60-year-old group and the 70-year-old group, while the occipital region of the female 60-year-old group showed a specific decline
Table 2 Brain regions with decreased metabolism in female Xincheng
Table 2 Brain regions with decreased metabolism in female XinchengTable 3 Brain regions with increased metabolism in women
Table 3 Brain regions with increased metabolism in womenTable 4 Brain regions with reduced metabolism in men
Table 4 Brain regions with reduced metabolism in menTable 5 Brain regions with increased metabolism in men
Table 5 Brain regions with increased metabolism in men
4.
Metabolic trends with age
Metabolic trends with age
Previous literature has shown that there is a certain difference in the trend of brain metabolism between males and females
.
In the authors' study, it was found that men's brain aging started at the age of 60 and manifested more after the age of 70, while women's brain aging started at the age of 60, and the age of 70 was less than that of the age of 60
Previous literature has shown that there is a certain difference in the trend of brain metabolism between males and females
.
In the authors' study, it was found that men's brain aging started at the age of 60 and manifested more after the age of 70, while women's brain aging started at the age of 60, and the age of 70 was less than that of the age of 60
.
These data suggest that women may age more slowly than men
.
This condition may be related to hormone levels.
Studies have shown that estrogen has a certain correlation with emotional control, cerebrovascular and neuronal protection, and the use of estrogen replacement therapy can reduce the risk of AD in women
.
To sum up, the following conclusions can be drawn from the author's research: (1) From the age of 60, it was found that the brain metabolism of the subjects decreased significantly, especially the bilateral frontal lobes, bilateral temporal lobes and the inferior cingulate gyrus, regardless of whether gender; (2) the authors identified gender-specific differences in brain metabolism, including regions of the caudate nucleus in men and regions of the occipital lobe in women; and (3) gender-specific aging trends
.
.
However, the author's research also has some limitations, the main limitation is the number of samples, and the number of samples needs to be expanded for more detailed research in the later stage
.
The aging of the two human brains is changing.
In the author's study, the data was collected at the age of 40, and the change data and trend of brain metabolism before the age of 40 were not obtained.
It is necessary to collect samples before the age of 40 and after the age of 80.
further research
.
.
The main limitation is the sample size, which needs to be expanded for more detailed research in the later stage
.
The aging of the two human brains is changing.
In the author's study, the data was collected at the age of 40, and the change data and trend of brain metabolism before the age of 40 were not obtained.
It is necessary to collect samples before the age of 40 and after the age of 80.
further research
.
references
references
Bei Feng, Jiang Cao, YaPing Yu, HaiYan Yang, YangHongYan Jiang, Ying Liu, Rong Wang and Qian Zhao, Gender-Related Differences in Regional Cerebral Glucose Metabolism in Normal Aging Brain, Front.
Aging Neurosci.
, 10 February 2022, https: https://doi.
org/10.
3389/fnagi.
2022.
809767
Aging Neurosci.
, 10 February 2022, https: https://doi.
org/10.
3389/fnagi.
2022.
809767
Compilation author: The original beautiful girl (Brainnews creative team)
Compilation author: The original beautiful girl (Brainnews creative team)Reviewer: Simon (Brainnews Editorial Office)
Reviewer: Simon (Brainnews Editorial Office)- END -
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