Fudan University Cancer Research published: A new mechanism for hyperglycemia to promote tumor metastasis through megakaryocytes

Tumor metastasis is the main cause of tumor-related death and is regulated by many factors

Tumor metastasis is a complicated process

Glucose regulatory protein 75 ( GRP75 ) belongs to the heat shock protein 70 family, but it does not respond to heat, but to stimuli such as glucose

2021 Nian 9 Yue 17 days, Fudan University, Professor Liu Wen and Yang Yunlong researcher at Cancer Research Online published a report entitled Megakaryocytes mediate hyperglycemia-induced tumor metastasis research results, the researchers found that high blood glucose by affecting megakaryocytes GRP75 the production of platelets Promote tumor metastasis phenotype

The researchers used a mouse model of hyperglycemia-induced metastasis and observed that the glucose transporter in tumor cells was related to the size of the metastasis, but not to the rate of metastasis

Through the isolation of bone marrow primary megakaryocytes and a series of molecular biology experiments, the authors found that hyperglycemia can significantly up-regulate the expression of GRP75 in megakaryocytes through the transcription factor MYC .

Finally, in healthy volunteers who drank 5% glucose water, GRP75 in platelets was significantly increased, and platelet activity was significantly enhanced

This work found for the first time that hyperglycemia promotes platelet activation by affecting megakaryocytes, driving tumor metastasis in an indirect manner

Master of Wu Biying, the first author of this article

Professor Liu Wen of Fudan University and researcher Yang Yunlong are the co-corresponding authors of this article

Original link: https://cancerres.

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