Fudan University mBio published a paper: Discovering new key genes for latent HIV infection

Zhu Huanzhang team AIDS is an infectious disease caused by human immunodeficiency virus (HIV) infection that seriously endangers people's lives and health

In this work, the researchers verified the potential candidate gene FKBP3 that is potentially related to HIV-1 on the basis of the large-scale CRISPR-Cas9 gene knockout screening, and found that multiple HIV-1 latently infected cell lines Knockout of FKBP3 in the latent model of CD4+ T lymphocytes and primary CD4+ T lymphocytes can promote latent HIV-1 transcriptional activation; at the same time, studies have found that FKBP3 can interact with YY1, HDAC1 and HDAC2 proteins, and can indirectly bind to HIV-1 through YY1 LTR region, and recruit HDAC1 and HDAC2 to HIV-1 LTR region, causing the level of histone acetylation near the HIV-1 integration site to decrease, leading to HIV-1 latent; the researchers also found that when HIV-1 infects cells The human body’s inherent innate immunity can increase the expression level of FKBP3 by secreting IFN-gamma, thereby inhibiting HIV-1 infection and replication, and inducing HIV-1 latency

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