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On October 27, 2021, Beijing time, the Joint Center for Horticultural Biology and Metabolomics of Fujian Agriculture and Forestry University-University of California, Riverside (FAFU-UCR Joint Center) published the title "TMK -" in the international journal Nature.
based cell-surface auxin signaling activates cell wall acidification" ("TMK kinase-mediated cell surface auxin signaling activates cell wall acidification") research article
.
This work revealed that plants sense extracellular growth hormone through the cell membrane surface receptor-like kinase family protein (TMK), and activate the proton pump (H+-ATPase) on the cell membrane surface through specific phosphorylation, leading to acidification of the cell wall and promoting cell elongation And tissue growth
.
This research analyzed the mechanism of the "acid growth hypothesis" that has been unresolved in the field of botany: how does auxin promote cell growth quickly?
Auxin (auxin) is the first hormone found in plants, named for its growth promotion
.
As one of the most important hormones in plants, auxin participates in almost all the growth and development processes of plants and the process of adapting to complex environments
With the discovery and analysis of the auxin signaling pathway mediated by the receptor-like kinase TMK family, the all-round regulation mode of auxin from the cell membrane to the nucleus provides new ideas for the interpretation of the complex functions of auxin, and also for unlocking the auxin The acid growth hypothesis provides a new strategy
.
The research team of Fujian Agriculture and Forestry University-University of California Joint Center found that receptor-like kinase (TMK1) and multiple members of the proton pump family (H+-ATPase, AHAs) located on the cell membrane can specifically bind to protein profiles by immunoprecipitation.
.
Further real-time fluorescence energy resonance transfer experiments proved that auxin can induce the binding of TMK1 and AHA1 on the cell membrane in just a few seconds
Using plant hypocotyl cell elongation as a research model, the study found that in TMK deletion mutants, auxin cannot promote cell elongation
.
Using phosphorylation proteomics, it was found that the phosphorylation level of C-terminal 947 threonine of multiple AHA family members was also significantly reduced in the mutant, and its phosphorylation level could not be induced by auxin
This research reveals how plants can quickly respond to extracellular growth hormone signals to induce protein binding and modification to activate proton pumps, induce acidification of cell walls, and promote cell elongation and tissue growth.
On the other hand, from molecular mechanisms It is a very important breakthrough in the field of auxin to truly analyze the formation mechanism of the "cell acidification theory" at the level
.
The research was completed by the Fujian Agriculture and Forestry University-University of California, Riverside Joint Center, and Dr.
Lin Wenwei of the Joint Center was the first author
.
Professor Xu Tongda and Professor Zhu Xiaoyue of Fujian Agriculture and Forestry University participated in the research work
Article link: https://
