G protein coupled subject (GPCR) research papers and results.

From 17:00 last night to 1:00 a.m. today, scientists from the Shanghai Institute of Pharmaceutical Research of the Chinese Academy of Sciences, Shanghai University of Science and Technology, and Fudan University's School of Pharmacy have published three G-protein coupled subjects (GPCR) research papers in Nature and Nature Communications.
research results show the strong scientific research strength of Shanghai as one of the world's three major GPCR research centers.
yesterday's press conference, reporters learned that this is a six-year-long fierce academic competition, finally put Zhang Jiang in the field of GPCR research in the forefront of the world.
GPCR is the largest protein family in the human body, with 826 members, playing a very important role in various life activities.
people's sense of smell, taste, and even love at first sight, are related to this protein.
it has a very strange structure——— it crosses back and forth seven times on the cell membrane like a pin.
because of its complex structure, scientists have not been able to find a crystallization method until recent years, solving the mystery of its three-dimensional structure.
In this protein family, there are A, B, C, F four categories, of which class A "body size" is the smallest, so the structure is first resolved, and the class B molecule is larger, more complex structure, until 2013 to analyze the first trans-membrane region structure.
members of class B GPCR are considered potential drug targets for the treatment of metabolic diseases, cardiovascular diseases, migraines and osteoporosis.
as a new drug creation "national team", the Shanghai Institute of Pharmaceutical Research of the Chinese Academy of Sciences began to pay attention to and lay out in the field of GPCR research.
Pharmaceuticals has brought in Raymond Stevens, the world's top structural biology scientist, and his two students——— Wu Yuli and Zhao Qiang, to set up a research platform at the same time, began a moment of academic competition.
years, Wu Yuli's team has made important achievements in the field of GPCR, this time leading the world in the research of Class B GPCR.
, published in Nature in the early hours of this morning, is the crystalline structure of the full-length glucaucose glucaucose -glucose -protein protein, with a resolution of up to 3.0 E (1 E x 0.1 nanometers).
This is the first time that Chinese scientists have obtained the full-length structure of the Class B GPCR protein, although less than a month ago, foreign scientists released the full-length structure of the Class B GPCR protein obtained from frozen electromirror, but with an accuracy of only about 4 E.
's the difference? Liu Zhijie, deputy director of the iHuman Institute at the University of Science and Technology, said that 4 E precision to see the protein structure, see like a silhouette in the dark, and 3 E accuracy can see the five officials and limbs and other details.
only by looking at the details will it make sense for the creation of new drugs.
also surprised by the addition of glutatrophytin-like peptide-1s (GLP-1R).
as early as 2007, Wang Mingwei found the world's first small molecule agonist Boc5 for the subject, which, if available, could replace existing peptide drugs and bring more convenience to diabetics.
was not able to obtain the fine structure of GLP-1R at that time, the road to medicine was eventually abandoned due to the bumpy situation.
When GLP-1R is likely to be parsed, Wang Mingwei's team immediately committed itself to joining forces with Raymond, founding director of the iHuman Institute——— and Liu Zhijie, deputy director, to break through the bottleneck of the receptor protein's difficulty in stability, and finally saw the receptor's "true face of Lushan".
with a fine structure, a lighthouse was lit up for the development of new drugs that were targeted for development.
At the same time, the research team at the iHuman Institute of Science and Technology and its collaborators also made a breakthrough in F-type GPCR research——— not only analyzing the full-length structure of the Soothened (smooth) subject associated with the development of substrate cell carcinoma, but also discovering its potential drug action target ——— hinge area.
paper was published in nature.
high-level results erupt so intensively? This stems from the efficient and close cooperation of these ———, which set up the GCR Research International Alliance three years ago to help each other overcome difficulties.
past six years, the scientists have successfully analyzed the structure of 11 GPCR, published 12 research papers in top academic journals, and developed four related drug candidates.
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