 Home > Biochemistry News > Biotechnology News > Gan Lai announces that FXR agonist ASC42 has achieved good data in phase I clinical trials in the United States

Gan Lai announces that FXR agonist ASC42 has achieved good data in phase I clinical trials in the United States

 Last Update: 2021-06-28
 Source: Internet
 Author: User

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Gan Lai Pharmaceutical announced on the 16th that its non-alcoholic steatohepatitis drug candidate farnesol X receptor (FXR) agonist ASC42 has achieved good safety and pharmacodynamic biomarker top-line data in the Phase I clinical trial in the United States

The Phase I trial of ASC42 in the United States is the first randomized, placebo-controlled, double-blind, single-dose and multiple-dose escalation and food-effect clinical trial conducted in humans

Based on the animal models of non-alcoholic steatohepatitis in mice and rats, it is predicted that the therapeutic dose for humans is 15 mg once a day, each time

Overall, ASC42 showed good safety and tolerability

In addition, the test results show that high-fat meals have no significant effect on the pharmacokinetic parameters of ASC42

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