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    Home > Food News > Food Articles > Gao Caixia: CRISPR technology award 'absolutely not a surprise'

    Gao Caixia: CRISPR technology award 'absolutely not a surprise'

    • Last Update: 2021-03-13
    • Source: Internet
    • Author: User
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    2020 Nobel Prize in Chemistry was announced at 5:45 p.m. Beijing time on Oct. 7. Emmanuelle Charpentier, director of the Pathogen Institute at the Map Society of Germany, and Jennifer A. Doudna, a professor at the University of California, Berkeley and a professor at the Howard Hughes Institute of Medicine, were honored for "developing a genome editing method."
    as a scientist working on cutting-edge research on CRISPR plant genome editing techniques, gao Caixia, a researcher at the
    Institute of Genetics and Developmental Biology, often meets and communicates with the two winners at international conferences. Upon learning of the award, she wrote an email congratulating the two of them the first time.
    no surprise that the "CRISPR technology" won the Nobel Prize. In an interview with China Science Daily, Gao Caixia said, "Since the day of its birth, everyone is looking forward to it to win the prize, this is the thing that everyone wants to return, it is the sooner or later thing." "
    's definitely not surprising, since the day it was born, everyone is looking forward to it winning, it's something that's to be hoped for, it's a matter of time, and I feel like it's going to happen soon."
    , the technique was quickly used by scientists around the world in different species, including humans, animals and plant cells, after it was shown to have shear activity in in-body in 2012. Second, over the years, this gene-editing tool has become more efficient, and almost all molecular centers and laboratories around the world are dependent on it. Just as without PCR (polymerase chain reaction), I can't imagine a molecular biology laboratory working efficiently without CRISPR in the near future.
    's patents are leading the way in the U.S., but in Europe, Doudna is the first to do so. This difference may also be related to the patent system.
    Zhang Feng did not list among them did have some regrets, but it is not surprising. I always thought it might be three scientists who won the award - Charpentier, Doudna and Zhang Feng. In June 2012, Doudna first published in Science the feasibility of CRISPR gene editing techniques for accurately cutting DNA in test tubes. In January 2013, Zhang Feng announced its use in animal and human cells. This is a very important step because previous systems have worked perfectly in primary nucleocytes, but not in the nucleocytes. But some would argue that if Zhang Feng were added to Lithuania's Virginijus Siksnys, it would be four men.
    could also be Charpentier, Doudna and Maria Jasin, who first demonstrated that DOUBLE-stranded DNA can increase gene editing efficiency, and last year won the Yifu Prize for Life Sciences and Medicine.
    but in any case, Charpentier and Doudna are definitely two of them.
    its greatest significance is to edit DNA sequences very precisely, using targeting as a metaphor, through which it can "point to where to hit." Previous genome editing or genome engineering is not widely adaptable, the technology is somewhat difficult, few laboratories can master this technology. With CRISPR, "the old king XieTang Before Yan finally flew into the ordinary people's home." Compared with the previous technology, it is simple, easy to learn, cheap, greatly reduce the entry threshold, and more importantly, it is also more efficient to target, can be targeted at multiple targets at the same time editing and decoration.
    technology is so significant that it covers every aspect of our lives, including agriculture, medicine, industry, the environment and so on. Imagine how much produce can be cultivated in the shortest possible time and with the most precision. In the treatment of diseases, it is expected to achieve the treatment of a variety of major diseases such as tumors.
    may not be as obvious in China, but many other male and female scientists, especially in pi (principal researcher) or professor, are very disproportionate.
    the award was not given because of gender, but their work did prove to the world that women scientists can be as good as male scientists. Including yesterday's Nobel Prize winner in physics, there is also a woman scientist.
    meetings often come across, and when I saw the winning news, I was ready to send them an e-mail congratulatory message. I'm very excited to learn that they've won, because we're all using this tool, or we're improving it further. A friend was sitting in the office talking to me, and I didn't even hear what he said.
    dodona is very slim, competent, especially professional, and she gives you a high opinion every time you finish a report exchange. She is easy to communicate with people, including when we have meetings and often invite her. We often send e-mails between us.
    than Doudna, I have less contact with Charpentier, she doesn't speak much, but you can feel that she is a very good scientist, she will have a meeting to discuss with you. The hiring of her as director of the Institute of Pathogen Science by the German Magnate Society is also an affirmation of her work.
    award is certainly the most original award, and neither scientist is in China, at least to say the least, we didn't really get the first say in the original. But China is still ahead of the curve in the optimization and application of CRISPR. In the field of plant genome editing, more than half of patents and articles come from China. In animal and medical areas, many jobs are also at the forefront of the world, such as the macaque-related research conducted by Mr. Ji Weizhi of Kunming University of Technology.
    foreign countries may pay more attention to crispr technology in disease treatment and other applications, China is a large agricultural country, the country also invested a lot of money in agriculture, genome editing is conducive to ensuring food security, China has a large number of outstanding scientists in this regard.
    on ethical issues, He Jiankui's CRISPR editor Baby is a wake-up call. In fact, before this, china has a very strict relevant ethical guidelines, but this study did not comply with the relevant requirements.
    CRISPR technology itself from the emergence to perfection of certainly need to go through a certain process. The tools in the toolbox are always as complete as possible so that a particular tool can do something specific. Clinically specific requirements for the tool itself are very high: first, whether CRISPR can be accurately delivered to cells, this is a bottleneck; Scientists are trying to make the tool better, so it hasn't gone that fast. It is believed that these technical issues will be resolved.
    for some jobs, such as the use of agricultural production, it has been able to meet our goals or objectives. For crops and plants, it doesn't matter if there are off-target, because the plant materials we use are offspring, and we can separate off-target mutations through off-target genetics. Plant research does not involve ethical issues, and the off-target requirements for CRISPR tools are not so high. Therefore, I hope that the country can soon in the regulation of gene-editing plants to introduce science-based regulations to promote our country in the industrialization of the move forward.
    genetically modified crops must integrate exogeneted genes into the plant genome, and it is exogeneted genes that are functioning. For example, the integration of exo-resistant insect-resistant genes. In fact, GM is safe for breeding, but it will take some time for the public to accept it.
    CRISPR technology can add nothing external, just modify the original sequence. If there's a little bit more of this sequence, you can cut it off; if the four-letter ATCG that make up the DNA is wrong, you can wipe it off like an eraser with CRISPR and turn A into G with a pencil, which is not left in the cell.
    it's so useful, whether it's for health care or for crop improvement. In the case of plants, the advantages of plants are obvious compared with traditional breeding techniques. For example, when high- and low-yielding crops are hybridized, high-yielding crops may be disease-resistant, while low-yielding crops may be disease-resistant, and hybridization is required if the disease-resistant symptoms are to be transferred to high-yielding crops. After hybridization, it also needs 6 to 8 generations of return, in order to make crops high-yield, disease resistance. And the premise is that hybrid parents have disease-resistant genes, and the whole process is very long.
    , scientists have managed to blindly create a variety of mutants through radiation, chemical mutagenics and other methods, to find the mutants they want is the same as looking for a needle in a haystack. Genome editing does not require thousands of mutants, but rather directs the production of the desired mutants, saving time and effort. And mutant material has long been present in the field, why can't genome editing be used? It's no use putting this principle into a clear sense. Therefore, in agriculture, CRISPR technology and other extension and application prospects are very promising.
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