Gao Fu talks about the development of the new crown vaccine: inactivated vaccine China went very fast feedback effect is also very good

Recently, a number of new crown vaccines have been approved and began to be vaccinated on a large scale in many countries.
china to overcome difficulties, with a rigorous and standardized attitude to vaccine research and development ... What are the different types of vaccines worldwide today? What is the process of vaccine research and development in China? What new understanding do scientists have about the new coronary pneumonia virus? What should people think of the effectiveness of vaccines? Focusing on the hot issues of concern to netizens, the reporter interviewed Gao Fu, a member of the Chinese Academy of Sciences and director of the China Center for Disease Control and Prevention.
following is the transcript of the interview: Reporter: In the fight against the new crown pneumonia epidemic and the protracted war, researchers are also in the laboratory with the virus "battle", in the process what efforts they have made? Gao Fu: To prevent and control infectious diseases, vaccines are the last way to solve them.
the end of January and the beginning of February this year, the Chinese Center for Disease Control and Prevention's virus agency has begun screening for the seeds of the vaccine.
At the same time, at the beginning of this year, when there was no experimental environment for the manufacturers, it was important to make such a crucial decision by lending the Biosecurity Level III Laboratory (P3 Laboratory) to the Beijing Biological Products Institute of Chinese Biology and the Beijing-based Company of Science and Technology to jointly develop the new coronary pneumonia inactivated vaccine.
why? Because the development of a vaccine for new coronary pneumonia must be carried out in the P3 laboratory environment, we all know that when the P3 laboratory operation, the risk is still very high.
: The CDC doesn't make vaccines itself? Gao Fu: Our CDC is a technical support department, we have early research and development, but to produce vaccines, or rely on large companies to do.
I think our CDC scientists, scientists, they can be responsible, dare to assume, out of the laboratory quickly into vaccine research and development, these things have been taken down.
: What are the different types of vaccines worldwide today? Gao Fu: At present, there are seven types of vaccines developed at home and abroad, namely inactivated vaccine, weak virus vaccine, viral vector vaccine, protein sub-unit vaccine, DNA vaccine, nucleic acid vaccine, nanoparticle vaccine.
in accordance with our country's five routes, there are inactivated vaccines, influenza virus as a vector of weak virus seedlings, adenovirus vaccines, nucleic acid vaccines, protein sub-unit seedlings.
The three fastest inactivation seedlings in our country are now nearing the end of Phase III clinically, and I believe you will hear its results in the near future, as far as I know, the situation should be very good."
addition, my research team and Zhifei cooperation of the protein sub-unit vaccine, has also entered the third phase of clinical.
I'm sure your next question will be to ask me, why is the vaccine suddenly going fast in the United States? Why is China's vaccine moving slowly again? That's normal.
why? First of all, we in China will be isolated viruses, sequencing results are open and transparent to the world, and soon entered the development of a new coronary pneumonia vaccine.
the same time, through efforts to fight the epidemic, the outbreak in Wuhan was soon brought under control, and when we studied the vaccine, there were no patients in China, so there was no environment for Phase III clinical trials.
like the United States, there are still many new coronary pneumonia patients.
, of course, why doesn't the West make inactivated vaccines? Inactivated vaccine production requires manufacturers to have biosecurity three-level protection standards, we were doing experimental P3 laboratory temporarily into a vaccine-producing environment, there are a lot of biosecurity issues, they do not, so inactivated vaccine line did not go.
the mRNA vaccine route they followed, a vaccine for cancer patients that treats cancer and is not the same for patients as it is for healthy people.
I'm not saying if it's going to have side effects in the future, but at least it's not ruled out, because humans will be the first to put the mRNA vaccine on healthy people, so there's a safety issue behind it."
as a professional, we must analyze good or bad, which is a scientific attitude.
for now, the inactivated vaccine was well laid out at the time, and we went very fast, and the feedback in some places was very good.
We are not faster than the vaccine who is slower, who is good and who is bad, is now compared to the virus, see who can block the virus, our competitors are viruses, not Europe, the United States or which country, nor is the competition between companies, human beings to unite.
General Secretary also said that vaccines are global public products, and we use public products to jointly eliminate the virus.
I personally think that if different companies, different countries take different paths at this time, and finally prove that one, two or three are the best, this is a good thing for human beings, if we follow a route to do, what if there is a problem?" At first we knew too little about the new coronary pneumonia virus, so China began to lay out five routes, and we developed them together.
I would like to remind you that we should have confidence in China's vaccines, in Chinese scientists, and in People in Public Health in China.
: Maybe a lot of people's initial feeling about vaccines is, "I get a shot and I'm not going to get sick."
"After many years of understanding of vaccines, how should the effectiveness of vaccines be viewed correctly?" Gao Fu: How to let everyone understand each other, this is what I am thinking.
the public is normal to question the vaccine, why is the flu vaccine played every year? Why didn't AIDS come up with a vaccine?
n't say a vaccine, a shot everything tube, different viruses have different characteristics, not that the vaccine doesn't work, we don't want to doubt the vaccine, but at the same time we should also be aware of the limitations of vaccine prevention.
was wiped out, AIDS is still there, can not find a vaccine.
our understanding of HIV itself is too superficial, and the virus, in turn, is cunning.
New Coronary Pneumonia Virus, the 7th coronavirus infected with humans, the history of human victory over pathogenic microorganisms is very short, the 1918 pandemic, when the virus was not isolated; SARS, it took us six months to know what the virus is; HIV also took several years to isolate the virus;
also asked, in the 21st century, how can humans take this virus no way? If the new coronary pneumonia virus and the previously known coronavirus are the same, this problem has long been solved, the reason can not be solved now, is because the virus has a lot of particularity, there are many scientific problems left here.
but the available data tell us that we are confident that vaccines will at least prevent and control the disease, but we cannot say that there is not a patient.
so we must believe in science, but also to give science time, scientific judgment, scientific cognition, are time-needed.
: Just now you said in the gradual understanding of the new coronary pneumonia virus, in fact, we have been "fighting" with it for a long time, do you now find a clearer law? Gao Fu: We are becoming more and more aware of the hidden and cunning nature of the virus.
back to the question of traceability, which is a scientific issue.
we all followed MERS's prescriptions, single-peak llamas with MERS virus, single-peak llamas and human contact infection.
H7N9, H5N1, is the chicken with the virus caused by human infection.
in the direction of animal-sourced diseases, it is now suspected internationally that the new coronary pneumonia virus must also have an animal carrier.
've been doing virology for so many years, and now I'm reflecting on myself, right? I myself went to Wuhan to turn over the box to find animals, the surrounding animals also looked for a circle, did not find.
there was a time when the roller coaster had coronavirus, and later it was found to be completely different from the new coronary pneumonia virus.
also have coronavirus, which is similar, but not the same.
if the new corona pneumonia comes from a bat, you'll have to find the virus from the bat, at least not so far.
don't rule out that the voice hasn't dropped, someone said it was found from the bat tomorrow, but it hasn't been found yet.
like bird flu, MERS was found all at once.
: News reports that otters are infected with the new coronary pneumonia virus, could it be it? Gao Fu: The current theory is that the virus carried by human beings infects otters, re-infects people from otters, not that otters infect people from the beginning, infects otters from breeders infected with new crowns, and then returns to people from otters, and mutates.
so three levels: common sense, knowledge, science.
virus in accordance with the common sense of the past, knowledge has not been said to have passed, leaving us a lot of scientific problems, that is only good back to science slowly to study.
: Could it not be found for a long time? Gao Fu: It's entirely possible, it's possible that the virus is gone, but we haven't found out exactly where it's from.
: Is this also the cunning of the virus? Gao Fu: Yes, from the beginning to today so many asymptomatic infections, this virus is very cunning.
reporter: asymptomatic patients themselves do not know, but he will have the pathogenesis process? Gao Fu: Some people show asymptomatic symptoms because of their long incubation period.
people have been asymptomatic.
this has been asymptomatic or light patients, may not stimulate antibody response, immune response.
, this began to reflect on the British proposed group immunity, perhaps it will not work.
After all, group immunity is pinning its hopes on exposing large groups to the virus, and many people are asymptomatic or light and may not be immune, and now it seems that this strategy may not work, nor can it be said to be 100 percent.
shows once again that this is a cunning virus, and we can only get to know it step by step.
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