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    Home > Biochemistry News > Biotechnology News > Gao Jianqing and Han Min's team from Zhejiang University School of Pharmacy, Zhejiang University reported in Nature Communications to respond...

    Gao Jianqing and Han Min's team from Zhejiang University School of Pharmacy, Zhejiang University reported in Nature Communications to respond...

    • Last Update: 2022-08-10
    • Source: Internet
    • Author: User
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    On May 25 , 2022 , the team of Professor Gao Jianqing and Associate Professor Han Min from the School of Pharmacy, Zhejiang University proposed a new strategy for the prevention and treatment of tumor metastasis by constructing a responsive post-assembly "polypeptide nanoblanket " in viv.


    Tumor-associated secretory factor ( TDSF ) is secreted by orthotopic tumors to induce the development of a pre-metastatic microenvironment before circulating tumor cells actually reach and colonize distant organs at potential metastatic ris.


    Based on the successful construction of an animal model of the pre-metastatic microenvironment, the research team recorded the dynamic pathological processes of the stromal microenvironment and the immune microenvironment during the development of the pre-metastatic lung microenvironment, including: fibroblast activation , deposition of extracellular matrix components, increased angiogenesis and permeability, and recruitment of bone marrow-derived immunosuppressive cells ( MDSC ) to exert immunosuppressive functio.


    Based on the pathological characteristics of the pre-transfer microenvironment, the research team designed and constructed the pre-transfer micro-environment responsive post-assembled polypeptide molecule FR17 , and examined the film blanket formed by the polypeptide molecule after the pre-transfer micro-environment was fixed and assembled by various technical mea.


     

    Polypeptide FR17 ​​self-assembles to form a "polypeptide nanocarpet" after tumor supernatant stimulation, inhibiting the activation of fibroblasts

    Mechanistic studies reveal that the "polypeptide nano-blanket" formed by responsive post-assembly inhibits the development and formation of the pro-metastatic matrix microenvironment by inhibiting the activation of fibroblasts during the early formation of the pre-metastatic microenvironment; suppressing matrix remodeling, angiogenesis and infiltrati.


    Polypeptide FR17 ​​showed good anti-metastatic effect in melanoma lung metastasis model and recurrence and metastasis model after orthotopic tumor resectio.



    The first author of the research paper is Zhou Yi, a doctoral student from the School of Pharmacy, Zhejiang University, and the corresponding authors are Professor Gao Jianqing and Associate Professor Han Min from the School of Pharmacy, Zhejiang Universit.


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