Gaofu team Cell Reports publishes research on new mechanism of GITR/GITRL identification

Tumor necrosis factor superfamily (tumor necrosis factor superfamily, TNF superfamily) related molecules are the key to natural/acquired immune regulation and function.

GITR is an immune checkpoint molecule involved in the regulation of T cell responses.

The GITR/GITRL discovered in this study is different from the "atypical" interaction mode of the classic TNF/TNFR superfamily, which not only expands our understanding of the molecular interaction mode of the TNF/TNFR superfamily, but is also based on the GITR/GITRL interaction.

In recent years, the team has carried out a series of research work on the ligand recognition mechanism of immune checkpoint receptor molecules and the mechanism of antibody drug action.

Zhao Min, an assistant researcher at the Institute of Microbiology, Chinese Academy of Sciences, and Fu Lijun, a postgraduate student jointly trained by Jiangxi Science and Technology Normal University, are the co-first authors of the study.

Link to the paper: https://