Gas production reaction (3)

Case 5

A researcher post-processed a large reaction of ester reduction with LiAlH ₄

Figure 24-32 Screenshot of the accident video

Reason analysis: The temperature of the reaction liquid to be quenched is lowered too low, and the concentration of the quencher NaOH solution is too high.

In addition to the electric spark inside the motor that can detonate the hydrogen explosion, there are two other factors that are also worth paying attention to: First, after the quenching reaction suddenly erupts, the balloon bursts, and the rushed reaction liquid flows into the water bath, which contains LiAlH ₄ and the water bath.

5.

If flammable and explosive gas is generated, there must be a safe distance between the gas outlet and the fire source (electric spark in the appliance)

A R&D staff made the following response:

The party involved cooled the reaction system (3L three-necked flask) with an ice-salt bath, and added 100g of sodium scraps into 1L methyl tert-butyl ether solution containing 300mL 2-butanone and 307mL ethyl formate in batches , and stirred with a mechanical stirrer.

Figure 24-33 is the photo after the explosion has been extinguished

Figure 24-33 The photo after the explosion and combustion have been extinguished

In addition, the cuffs of the experiment suit caught fire, the back of the hand was burned, and the face and hair were scorched by the fire

The direct cause: The reaction setting is unreasonable.

Indirect reasons: weak safety awareness of R&D personnel, inadequate training, failure of relevant management personnel to provide timely guidance, ineffective supervision, failure to detect hidden dangers in time and stop their illegal operations

Related Links: Gas Production Reaction (2)