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    Home > Active Ingredient News > Digestive System Information > Gastric Cancer: Application of one-step nucleic acid amplification detection in outpost lymph node location in early gastric cancer patients.

    Gastric Cancer: Application of one-step nucleic acid amplification detection in outpost lymph node location in early gastric cancer patients.

    • Last Update: 2020-07-27
    • Source: Internet
    • Author: User
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    !---- The accuracy of the diagnosis in the procedure is essential for the safe implementation of minimal gastric resection based on the concept of outpost lymph nodes (SN) in patients with early gastric cancercompared to histopathological examination, the purpose of this study is to assess the clinical usefulness of one-step nucleic acid amplification (OSNA) analysis in diagnosing SN metastasis in early gastric cancer patientsmethod researchers used OSNA analysis to conduct a prospective study of cT1N0M0 gastric cancer patients with 43 routine SN gastric excisioncheck all SNs and selected non-SNs through routine histopathological diagnosis and OSNA analysisresults Researchers conducted histopathological examinations on 1,732 lymph nodes (LNs) (286 SNs and 1446 non-SNs) in 43 patientsIn addition to the pathology examination, the439 LNs (286 SNs and 153 non-SNs) were assessed through OSNA analysisintraoperative histopathology (IH) was performed in 214 LNs (213 SNs and 1 non-SN)pathology tests showed lN metastasis in 6 patients (14%) and all patients tested positive for pathologythe diagnostic accuracy of predicting LN status based on The SN concept is 100% through histological examinationcompared with histology, the sensitivity and specificity of OSNA measurements were 0.636 and 0.988, respectivelyconclusion OSNA assay is a useful and convenient tool for detection of SN metastasis in early gastric cancer patients.
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