Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death in the world, surgical excision is the most effective means of treating advanced stomach cancer, but postoperative complications can adversely affect the quality of life of patients and may even lead to death, and recent studies have found that postoperative complications are associated with long-term survival outcomes in patients with postoperative gastric cancer.
not fully explained, it is likely that the growth of residual cancer cells is due to surgical stress or postoperative complications.
The purpose of this study is to explore the effects of postoperative complications on long-term survival outcomes in patients with gastric cancer surgery, as well as the lifetime effects of cystic excision and non-cystic excision in patients with T3/4a localized advanced gastric cancer in T3/4a.
the study included 1,191 eligible patients.
complications are graded by the Clavien-Dindo (CD) classification.
A single-variable and multivariate analysis using the Cox proportional risk model resulted in an assessment of the impact of the level of complications (≥CD grade II or ≥III) or type (any or intracarosis infection) on survival outcomes.
researchers found that the incidence of complications (≥CD II and ≥III) after gastric cancer surgery was 23.0% and 9.7%, respectively, and the incidence of complications of intracarosis in the celiac at ≥CDII and CD≥III was 13.4% and 6.9%, respectively.
analysis showed that all postoperative complications were independent prognostic factors for overall survival.
contrary, only ≥CD III-level complications were found to be independent prognostion factors that did not re-occur (risk ratio 1.445; 95% confidence interval 1.026-2.036; P s 0.035).
study concluded that postoperative complications can adversely affect the long-term survival of patients with cT3/4a stomach cancer.
cd≥-level complications seem to be the most appropriate indicator for predicting negative long-term survival outcomes.