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Lynch syndrome (Lynch syndrome (LS)) is an inherited cancer susceptibility syndrome caused by mutations in four mismatch repair (MMR) genes: MLH1, MSH2, PMS2 and MSH6.
This autosomal dominant genetic disease is characterized by an abnormally increased incidence of colorectal cancer (60-80%) and endometrial cancer (30-70%).
At present, colorectal cancer in LS patients has several clinicopathological features, but It is not very clear.
Therefore, in order to investigate the risk and clinicopathological characteristics of gastric tumors in LS, the researchers conducted a retrospective cohort study on Japanese LS patients.
Researchers collected clinical data of LS patients with pathogenic mismatch repair (MMR) gene variants from the LS registry of the National Cancer Center Hospital of Japan, and then used the Kaplan-Meier method to estimate the cumulative risk of gastric tumors, including development The incidence of ill health and cancer.
The condition of gastric atrophy was assessed by endoscopic and/or histological methods, and all available specimens were further analyzed by immunohistochemical staining of MMR protein.
Of the 118 eligible LS patients, 26 patients were diagnosed with gastric tumors.
At the age of 70, the cumulative incidence of gastric tumors was 41.
0% (95% confidence interval 26.
9-55.
0).
Among them, 13 patients (50%) developed multiple simultaneous and/or metachronous gastric tumors.
Among the 49 types of gastric tumors that can be used for detailed pathological evaluation, all are related to intestinal metaplasia.
Immunohistochemical analysis showed that 42 (86%) patients had MMR deficiency.
Compared with patients without gastric atrophy, patients with gastric atrophy had a significantly higher risk of gastric tumors (26/54 vs.
0/53) (P = 0.
026).Through this retrospective study, the authors found that: for LS patients, especially patients with atrophic gastritis, the risk of gastric cancer is high, and it often develops into multiple tumors.
For LS patients, especially patients with atrophic gastritis, it is recommended to conduct close endoscopic monitoring for gastric cancer.
Original source: Hourin Cho.
Et al.
Gastric cancer is highly prevalent in Lynch syndrome patients with atrophic gastritis.
Gastric Cancer.
2021.
This autosomal dominant genetic disease is characterized by an abnormally increased incidence of colorectal cancer (60-80%) and endometrial cancer (30-70%).
At present, colorectal cancer in LS patients has several clinicopathological features, but It is not very clear.
Therefore, in order to investigate the risk and clinicopathological characteristics of gastric tumors in LS, the researchers conducted a retrospective cohort study on Japanese LS patients.
Researchers collected clinical data of LS patients with pathogenic mismatch repair (MMR) gene variants from the LS registry of the National Cancer Center Hospital of Japan, and then used the Kaplan-Meier method to estimate the cumulative risk of gastric tumors, including development The incidence of ill health and cancer.
The condition of gastric atrophy was assessed by endoscopic and/or histological methods, and all available specimens were further analyzed by immunohistochemical staining of MMR protein.
Of the 118 eligible LS patients, 26 patients were diagnosed with gastric tumors.
At the age of 70, the cumulative incidence of gastric tumors was 41.
0% (95% confidence interval 26.
9-55.
0).
Among them, 13 patients (50%) developed multiple simultaneous and/or metachronous gastric tumors.
Among the 49 types of gastric tumors that can be used for detailed pathological evaluation, all are related to intestinal metaplasia.
Immunohistochemical analysis showed that 42 (86%) patients had MMR deficiency.
Compared with patients without gastric atrophy, patients with gastric atrophy had a significantly higher risk of gastric tumors (26/54 vs.
0/53) (P = 0.
026).Through this retrospective study, the authors found that: for LS patients, especially patients with atrophic gastritis, the risk of gastric cancer is high, and it often develops into multiple tumors.
For LS patients, especially patients with atrophic gastritis, it is recommended to conduct close endoscopic monitoring for gastric cancer.
Original source: Hourin Cho.
Et al.
Gastric cancer is highly prevalent in Lynch syndrome patients with atrophic gastritis.
Gastric Cancer.
2021.