Gastric Cancer: The potential role of non-typhoid salmonella in stomach cancer

Cancer is the biggest challenge in public health, and despite the efforts of researchers to fight it, it remains the main cause of death in humans.
the beginning of the twentieth century, infection has become a fundamental cause of cancer, and more and more pathogens are considered to be carcinogenic.
bacteria may be involved in the formation of cancer cells by causing inflammation, releasing toxins and metabolites and reprogramming the signaling pathways of host cells over their life cycle, identifying this infectious pathogen as an important and effective way to break this potentially carcinogenic chain and prevent normal cells from turning into cancer cells.
a recent study, non-typhoid salmonella (NTS) was found to be associated with colon cancer, and in the United States, the incidence of salmonella is more than 100,000 cases per year, and NTS is resistant to acidic environments in the stomach and in the large intestine. Because of the controversial effects of NTS on the digestive tract and its role in cancer, the researchers conducted a population-based longitudinal cohort study to provide epidemiological evidence of the potential role of non-typhoid salmonella infection in the subsequent development of stomach cancer.
conducted a retrospective study by analyzing hospitalization data from Taiwan's National Health Insurance Research Database.
NTS-infected patients aged 20 years and over between 1 January 2000 and 31 December 2012 (n s 9097) and followed up.
main observation is the incidence of stomach cancer.
use Cox proportional risk regression to estimate the risk of malignant tumors and consider the competitive risk of death.
addition, sensitivity analysis was performed over a one-year basis by tending to score matching and eliminating malignant tumors to minimize measurable confusion and primary bias.
the study included 18,194 patients (9,097 in both NTS and non-NTS groups).
of follow-up is 7 years.
incidence of stomach cancer in the NTS group was 0.72/1000 years, and in the non-NTS group it was 0.40/1000 years.
the NTS group had a slightly higher risk of stomach cancer than the non-NTS group (aHR, 2.02; 95% CI 1.18-3.45).
the study, the authors said: NTS infection patients have a significantly increased risk of stomach cancer compared to non-NTS infection patients.
further research is needed to see if NTS is related to the cause of stomach cancer or just parallel.