Gastroenterology: Antibiotic resistance genes in gut microbes in patients with liver cirrhosis

There are trillions of microbes in the human intestine that make up the intestinal flora.
Most of the bacteria are sensitive to antibiotics , but some bacteria are resistant to antibiotics
.

Previously, the team of Professor Willem van Schaik from the University of Birmingham found thousands of new types of antibiotic resistance in human gut bacteria by comparing the structure of known antibiotic resistance proteins with the structure of proteins produced by bacteria in the human gut.

There are trillions of microbes in the human intestine that make up the intestinal flora.

Cirrhosis of the liver and intestinal flora with customs, changes in the intestinal flora leads to hepatic encephalopathy and infection , especially antibiotic-resistant microbes

The researchers used metagenomics analysis of outpatients with liver cirrhosis to evaluate the changes in ARG abundance with the disease and its impact on 90-day hospitalization and mortality over 1 year

A total of 163 patients with cirrhosis (43 patients with compensatory phase, 20 patients with ascites, 30 patients with hepatic encephalopathy, 70 patients with both symptoms) and 40 controls were included in the study

Compared with the control group, liver cirrhosis is related to the high abundance of intestinal microbial ARG genes and worsens as the disease progresses, which may be different from CKD and diabetes

Original Source : Amirhossein Shamsaddini, Impact of Antibiotic Resistance Genes in Gut Microbiome of Patients With Cirrhosis .
, Gastroenterology, 2021,508-521.
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