In many countries, the incidence of colorectal cancer (CRC) among young adults is increasing
.
The rising trend of the incidence of young people may indicate that the risk factors of CRC have changed recently and may worsen the national medical burden caused by CRC
.
Therefore, the most important thing is to identify the key modifiable risk factors for early-onset cancer
.
Evidence from many studies shows that body mass index (BMI) is positively correlated with the risk of CRC
.
In addition, some studies have shown that early overweight and obesity may be particularly related to the risk of CRC
.
However, most of the evidence on the risk of BMI and CRC comes from studies that include participants of all ages, and the vast majority of them are people over 60
.
It is unclear to what extent and to what extent overweight and obesity of different age groups are related to the risk of CRC
.
In particular, it is not clear to what extent overweight and obesity of different age groups (such as 20 years old and 30 years old) are related to the risk of early-onset CRC
.
Therefore, this study aims to assess the association between BMI at different ages in early adulthood and early-onset CRC
.
.
The rising trend of the incidence of young people may indicate that the risk factors of CRC have changed recently and may worsen the national medical burden caused by CRC
.
Colorectal cancer
A total of 6,602 CRC patients and 7,950 matched controls were recruited from 2003 to 2020, of which 747 patients and 621 controls were under 55 years of age and were included in this analysis
.
In the personal interview , the self-reported height and weight of all patients at the age of 20 and 30 and approximately 10 years before the diagnosis or interview were recorded
.
Multiple logistic regression was used to estimate the association between BMI and early-onset CRC
.
The results of the study showed that compared with participants with a BMI of <25 kg/m 2 , participants with a BMI ≥ 30 kg/m 2 (obesity) at the age of 20 and 30 and approximately 10 years before diagnosis had 2.
56 (95% CI 1.
20-5.
44).
), 2.
06 (1.
25-3.
40) and 1.
88 (1.
30-2.
73) times the risk of early-onset CRC
.
The association between BMI and the risk of early-onset CRC was particularly evident in most participants who did not undergo colonoscopy, and was basically limited to these participants
.
The role of overweight and obesity as risk factors for CRC has long been proven
.
However, most previous studies have focused on CRC of all ages
.
Given that early-onset CRC only accounts for a small number of CRC cases, this study confirms that obesity in early adulthood is closely related to the increased risk of early-onset CRC
.
.
However, most previous studies have focused on CRC of all ages
.
Given that early-onset CRC only accounts for a small number of CRC cases, this study confirms that obesity in early adulthood is closely related to the increased risk of early-onset CRC
.
Original source:
Hengjing Li.
Et al.
Associations of body mass index at different ages with early-onset colorectal cancer.
Gastroenterology.
2021.
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