Gastroenterology: Predictor of chronic fatigue in adolescents six months after acute EB virus infection.

Acute EBV infection is a cause of chronic fatigue and chronic fatigue syndrome (CFS).
study investigated baseline predictive factors for chronic fatigue 6 months after acute EBV infection.
researchers evaluated 149 possible baseline predictors in 200 adolescents (12-20 years old) with acute EBV infection and followed them forward-lookingly.
we performed linear regression to assess a possible association between baseline predictors and fatigue (chalder fatigue questionnaire score) six months after acute EBV infection.
a total of 70 health control groups were included as cross-sectional references.
the study is part of the CEBA-Project ( Chronic Fatigue after Acute EB Virus Infection in Adolescents).
results show that in the final multilinear regression model, fatigue in the 6 months after acute EBV infection was significantly and independently predicted by the following baseline variables (regression coefficient B (95%CI)): sensory sensitivity (0.8 (0.09 to 1.6)), pain severity (0. 2 .02 to 0.3), Dysfunction (1000 steps/day) (-0.3 (-0.5 to -0.08), negative emotions (anxiety) (0.4 to 0.2 to 0. 6) ), speech memory (positive confirmation word) (1.7 (0.1 to 1.3), plasma C reactive protein (CRP value of 0.86, 2.8 (1.1 to 4.4) and plasma vitamin B12 (-0.005( -0.01 to -0.001).
overall, the results show that the development of fatigue after acute EBV infection is more predicted by baseline variables associated with symptoms and function than by baseline variables that reflect infection and immune processes.
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