Gastroenterology: Significant disruption of short-chain fatty acid and L-isoleucine biosynthesis in the gut microbiome of COVID-19 patients

Coronavirus disease 2019 ( COVID-19 ) , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily infects the respiratory system but also affects other organs including the gastrointestinal tract
.

Recent studies have reported alterations in the gut microbiome in SARS-CoV-2 infection, characterized by a reduction in beneficial (butyrate-producing) bacteria, such as several genera of the Ruminococcus and Lachnospira families, as well as opportunities for The enrichment of sexual pathogens, including Streptococcus, Rothella, Veillonella, and Actinomycetes

Coronavirus disease 2019 ( COVID-19 ) , caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily infects the respiratory system but also affects other organs including the gastrointestinal tract

 

The researchers performed shotgun metagenomic sequencing of stool samples from 66 antibiotic
-naïve COVID-19 patients and 70 non-COVID-19 control patients .

Corresponding stool samples were collected during hospitalization and more than 1 month after discharge

antibiotic

 

Results of the study showed significant changes in gut microbiome function in severe/critically ill COVID-19 patients compared with non-COVID-19 controls (P < .
001), characterized by gut microbiome effects on SCFA and L- Isoleucine biosynthesis is impaired and urea production is increased
.

Impaired SCFA and L-isoleucine biosynthesis in the gut microbiome persisted for more than 30 days after recovery in COVID-19 patients

 

This study demonstrates that the gut microbiome of COVID-19 patients shows impaired SCFA and L-isoleucine biosynthesis that persist even after disease resolution
.

These two microbial functions are associated with host immune responses, emphasizing the importance of gut microbial function in the pathogenesis and outcome of SARS-CoV-2 infection

This study demonstrates that the gut microbiome of COVID-19 patients shows impaired SCFA and L-isoleucine biosynthesis that persist even after disease resolution

 

Original source:

FenZhang.

Prolonged Impairment of Short-Chain Fatty Acid and L-Isoleucine Biosynthesis in Gut Microbiome in Patients With COVID-19.
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