Gastroenterology: Sulfur-containing diet will increase the risk of early-onset colorectal cancer

In the United States, the incidence of colorectal cancer (CRC) has increased among people aged 20-49 years
.

Patients with early-onset CRC, or CRC before the age of 50, are usually diagnosed at a more advanced stage, and this unique tumor subtype has a higher aggressiveness

In the United States, the incidence of colorectal cancer (CRC) has increased among people aged 20-49 years

Studies have shown that diet may increase the incidence of colorectal cancer (CRC) before the age of 50 (early-onset CRC)
.

The microbial metabolism of dietary sulfur produces hydrogen sulfide (H 2 S), a gastrointestinal carcinogen that is difficult to measure on a large scale

The researchers evaluated the long-term adherence of the sulfur-containing microbial diet to all patients.
The diet index was pre-defined based on the increase in the abundance of 43 bacteria related to sulfur metabolism.
A total of 59,014 individuals were at risk of CRC precursors.
A validated food frequency questionnaire was used for dietary assessment and a quantitative analysis of dietary intake during adolescence in 1998
.

Finally, multivariate logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI)

A total of 2911 cases of early-onset adenomas were recorded in this study
.

After adjusting for the identified risk factors, a higher sulfur-containing microbial diet score was associated with an increased risk of early-onset adenoma (OR: Q4 compared with Q1, 1.

 

Finally, this study confirmed that a higher sulfur-containing microbial diet in early adulthood is associated with an increased risk of early-onset conventional adenomas, especially those with higher-risk histological characteristics
.

Finally, this study confirmed that a higher sulfur-containing microbial diet in early adulthood is associated with an increased risk of early-onset conventional adenomas, especially those with higher-risk histological characteristics
.

Original source:

Long H.

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