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    Home > Active Ingredient News > Digestive System Information > Gastroenterology: Symptoms and Risk of Refractive Gastroesophageal Reflux Disease of Proton Pump Inhibitors

    Gastroenterology: Symptoms and Risk of Refractive Gastroesophageal Reflux Disease of Proton Pump Inhibitors

    • Last Update: 2020-06-23
    • Source: Internet
    • Author: User
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    Recently, researchers conducted a population-based study examining the effects of the use of proton pump inhibitors (PPI) on gastroesophageal reflux disease (GERD) symptoms and persistent symptomsMyGiHealth study began in 2015 with a national gastrointestinal surveyThe main result was the rate of GERD symptoms and persistent GERD symptoms in subjects taking PPIs (defined as heartburn or reflux for more than 2 days within a week)of 71,812 participants, 32,878 (44.1%) reported past GERD symptoms and 23,039 (30.9%) reported GERD symptoms in the past weekThe researchers also found that 35.1% of patients with GERD symptoms are currently being treated (55.2% using PPIs, 24.3% using histamine-2 blockers, and 24.4% using antacids)Of the 3,229 participants who took PPIs daily, 54.1% had persistent GERD symptomsYoung people, women, Latinos, and participants with irritable bowel syndrome or Crohn's disease are more likely to develop persistent symptoms, even when taking PPIsthrough a population survey, the researchers found that gastroesophageal reflux symptoms were common: two out of five participants had GERD symptoms in the past and one in three had GERD symptoms in the past weekThe researchers also found that half of PPI users had persistent symptomsGiven the significant impact of GERD on quality of life, patients with PPI refractive GERD symptoms need to further research and develop new treatments
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