echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Digestive System Information > Gastroenterology: Vitolic acid and lymphocytoxsignalation can promote differentiation of human intestinal M cells

    Gastroenterology: Vitolic acid and lymphocytoxsignalation can promote differentiation of human intestinal M cells

    • Last Update: 2020-06-22
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Background and objective: Intestinal microfolding (M) cells are unique subtypes of intestinal epithelial cells in the Peyer spot that regulate mucous membrane immunity and serve as the first line of defense for in-cavity antigen sampling and ingestionBut current technology is not effective in growing human M-cells in cell culture, which hinders research by the intestinal immune systemTherefore, the purpose of this study is to identify the signaling pathways needed for human M-cell differentiation and to establish a robust culture system using human intestinal-like substancesmethod: The researchers analyzed transcription data from mice Peyer's Patches to identify cell populations adjacent to M cells and used a human intestinal-like system to determine the cytokines needed to induce M-cell differentiationFinally, a transcription group, immunofluoresista, scanning electron microscope and transcell swallowing experiments were carried out to verify the development requirements of the metatype and functional human M cellsresults: This study found that a combination of retinoid acid and lymphocytoxin induces glycoprotein 2-positive human M-cell differentiation, which lacks a top microfluorous structureAfter rotavirus infection, the expression of congenital immune-related genes in M cells was associated with the lack of viral antigensHuman M cells developing in the intestinal-like system internalize and transport enteroviruses, such as rotaviruses and exoroviruses, through the intestinal epithelial barrier in the intestinal sampleconclusion: This study identified the signaling pathways needed for intestinal M cell differentiation and used this information to create a powerful culture method for developing human M cells with viral internalization and transport capabilities
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.